[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-367104-105":59,"doc-detail-367104-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","a-perspective-on-lung-cancer-and-lung-microbiome-insight-on-immunity-review-article","A Perspective on Lung Cancer and Lung Microbiome - Insight on Immunity - Review Article","","Microbes are widely recognized for carcinogenic potential, yet their contribution to cancer has often been underestimated. This review synthesizes research on the lung microbiome and lung cancer, emphasizing how lung microbiota reflects lung health through maintenance of hemostasis. Literature searches indicate dysbiosis can affect tumor development and spread, and microbiota profiles may support early diagnostic biomarkers while also participating in anticancer therapy. Human and animal evidence suggests microbiome composition shifts in lung cancer patients.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-perspective-on-lung-cancer-and-lung-microbiome-insight-on-immunity-review-article/367104/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-perspective-on-lung-cancer-and-lung-microbiome-insight-on-immunity-review-article/367104.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main focus of the review?","Question",{"text":113,"@type":114},"The review outlines current understanding of how the lung microbiome contributes to lung cancer and immunity-related mechanisms, including diagnostic and therapeutic implications.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does dysbiosis relate to lung cancer in the review?",{"text":118,"@type":114},"Early studies described in the review suggest dysbiosis can significantly impact tumor development and spread, supporting interest in lung microbiota as a target.",{"name":120,"@type":111,"acceptedAnswer":121},"What evidence about lung microbiota differences is summarized in the conclusion?",{"text":122,"@type":114},"The review states that data from humans and animals indicate microbiota may influence cancer initiation, with reduced diversity in lung cancer patients and altered genera compared with noncancer populations.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},367104,1790309751,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Immunity, Inflammation and Disease  \nREVIEW ARTICLE   \nA Perspective on Lung Cancer and Lung Microbiome: Insight on Immunity  \nReza Emadi1 | Sasan Saki1 | Parastoo Yousefi2  | Alireza Tabibzadeh1,3   \n1Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Arak Branch, Arak, Iran | 2Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran | 3Applied Neuroscience Research Center, Islamic Azad University, Arak Branch, Arak, Iran  \nCorrespondence: Alireza Tabibzadeh ([Alireza.tabibzadeh@outlook.com](Alireza.tabibzadeh@outlook.com))  \nReceived: 2 May 2024 | Revised: 3 January 2025 | Accepted: 19 January 2025  \nKeywords: carcinogenesis | lung cancer | microbiome | microbiota  \nABSTRACT  \nBackground: Although the carcinogenic potential of microbes has long been recognized, their significance may have been underestimated. Currently, the connection between microbiota and cancer is under extensive research. The lung microbiota may serve as a proxy for the state of lung health based on its crucial role in preserving lung hemostasis.  \nObjectives: This review tried to outline the state of our understanding of the contribution of lung microbiome and lung cancer. Methods: A literature search was performed using PubMed, Google Scholar, and Scopus databases for recent research focusing on the development and possible pathogenesis of lung microbiome and lung cancer.  \nResults: Early research on lung cancer indicated that dysbiosis significantly impacted the development and spread of the tumor. As a result of these findings, the study of the lung microbiota as a possible therapeutic target and diagnostic marker has accelerated. Early‐stage disease diagnostic biomarkers could be represented as microbiota profiles. Additionally, the microbiome is involved in anticancer therapy. There are limited studies on lung microbiota, and most microbiome studies commonly concentrate on the gut microbiota. A proper understanding of lung microbiota can have several potential therapeutic approaches. Therefore, more studies in this field may initiate remarkable advancements in microbiome‐dependent treatment. Conclusion: Convincing data from studies on both humans and animals indicates that the microbiota might play a role in cancer initiation, influenced by internal and environmental factors of the host. Notably, the lung harbors its microbiome, as do lung cancers. In general view, it seems microbiome diversity in lung cancer patients is reduced. Meanwhile, some genera were increased in lung cancer patients in comparison with a noncancerous population (such as Streptococcus genus), and some of them were decreased (Granulicatella adiacens, G. adiacens) . Furthermore, research on the microbiome‐carcinogenesis relationship is still in its infancy, and much remains to be fully understood.  \n1 | Introduction  \nThe International Agency for Cancer Research states that at least 10 distinct biological agents, including bacteria, viruses, and parasites, have been linked to the etiology of cancer [1] . The microbiome's count and diversity differ from anatomical sites and are influenced by environmental and host variables that can play a role in disease and health [2] . Microbiota is a  \ncomponent of the innate immune system and regulates many host defense mechanisms [3] . The rates of immigration, elimination, and replication of the microorganisms influence the composition of this microbiota [4] .  \nInitially, epidemiological research on individuals could show the connection between microbes and cancer. According to certain research, bacteria have a part in the malignant transformation of  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s) . Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.  \nImmunity,","cbCaiaxO4ejEYyOp","https://ap.wps.com/l/cbCaiaxO4ejEYyOp","pdf",496537,"English","# Introduction\n## Microbiome and cancer etiology\n## Lung microbiota and lung cancer\n# Abstract\n## Background and objectives\n## Methods and results\n## Conclusion","[{\"question\":\"What is the main focus of the review?\",\"answer\":\"The review outlines current understanding of how the lung microbiome contributes to lung cancer and immunity-related mechanisms, including diagnostic and therapeutic implications.\"},{\"question\":\"How does dysbiosis relate to lung cancer in the review?\",\"answer\":\"Early studies described in the review suggest dysbiosis can significantly impact tumor development and spread, supporting interest in lung microbiota as a target.\"},{\"question\":\"What evidence about lung microbiota differences is summarized in the conclusion?\",\"answer\":\"The review states that data from humans and animals indicate microbiota may influence cancer initiation, with reduced diversity in lung cancer patients and altered genera compared with noncancer populations.\"}]","A Perspective on Lung Cancer and Lung Microbiome - Insight on Immunity - Review Article | PDF",1790169288,23]