[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333437-105":59,"doc-detail-333437-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-novel-signature-incorporating-genes-related-to-lipid-metabolism-and-immune-for-prognostic-and-functional-prediction-of-breast-cancer","A novel signature incorporating genes related to lipid metabolism and immune for prognostic and functional prediction of breast cancer","","Breast cancer prognosis and functional status have not been comprehensively evaluated through immunology and lipid metabolism together, and existing work lacks robust prognostic and functional analyses of their relationship. The study derived differentially expressed genes from UCSC and curated lipid metabolism and immune-related genes via GSEA and immune databases, then built a predictive signature using univariate Cox and LASSO regression and validated it with survival modeling and functional enrichment. Results identify 136 immune- and lipid-linked DEGs and a nine-gene model where IL18 supports prognostic guidance and immune regulation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-novel-signature-incorporating-genes-related-to-lipid-metabolism-and-immune-for-prognostic-and-functional-prediction-of-breast-cancer/333437/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-novel-signature-incorporating-genes-related-to-lipid-metabolism-and-immune-for-prognostic-and-functional-prediction-of-breast-cancer/333437.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of constructing the novel gene signature?","Question",{"text":112,"@type":113},"To predict breast cancer prognosis and provide functional insight by linking lipid metabolism-related and immune-related gene activity to clinical outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the predictive signature built and validated?",{"text":117,"@type":113},"Differentially expressed genes were obtained from UCSC, lipid metabolism and immune-related genes were gathered from GSEA and immune resources, and a signature was constructed using univariate Cox and LASSO regression, then assessed with Kaplan-Meier and time-dependent ROC plus survival risk scoring.",{"name":119,"@type":110,"acceptedAnswer":120},"Which key gene is highlighted, and why?",{"text":121,"@type":113},"IL18 is emphasized because it had not been previously reported in breast cancer within the context of the study’s signature, and it is used to explore function, outcome prediction potential, and immune-system involvement.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333437,1790528668,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 10  \nResearch Paper  \nA novel signature incorporating genes related to lipid metabolism and immune for prognostic and functional prediction of breast cancer  \nXiao Zhao1,*, Lvjun Yan3,*, Zailin Yang2, Hui Zhang2, Lingshuang Kong2, Na Zhang2, Yongpeng He2  \n1Clinical Laboratory, People’s Hospital of Xinjin District, Chengdu 611430, China  \n2Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing 400030, China  \n3Tumor and Hematology Department, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China  \n* Equal contribution and co-first authors  \nCorrespondence to: Lingshuang Kong, Na Zhang, Yongpeng He; email: [konglsh1203@163.com](konglsh1203@163.com), [https://orcid.org/0009-0001-](https://orcid.org/0009-0001-)[ ](https://orcid.org/0009-0001-)4481-4298; [zhangna@cqu.edu.cn](zhangna@cqu.edu.cn), [heyongpeng0320@163.com](heyongpeng0320@163.com), [https://orcid.org/0000-0002-2424-8743](https://orcid.org/0000-0002-2424-8743)[ ](https://orcid.org/0000-0002-2424-8743)[Keywords:](Keywords: lipid metabolism)[ lipid metabolism](Keywords: lipid metabolism), immunity, breast cancer, IL18, prognosis, RT-PCR  \nReceived: January 15, 2024 Accepted: April 10, 2024 Published: May 20, 2024  \nCopyright: © 2024 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nPurpose: Breast cancer prognosis and functioning have not been thoroughly examined in relation to immunological and lipid metabolism. However, there is a lack of prognostic and functional analyses of the relationship between lipid metabolism and immunity in breast cancer.  \nMethods: DEGs in breast cancer were obtained from UCSC database, and lipid metabolism and immune-related genes were obtained from GSEA and Immune databases. A predictive signature was constructed using univariate Cox and LASSO regression on lipid metabolism and immune-related DEGs. The signature’s prognostic significance was assessed using Kaplan-Meier, time-dependent ROC, and risk factor survival scores. Survival prognosis, therapeutic relevance, and functional enrichment were used to mine model gene biology. We selected IL18, which has never been reported in breast cancer before, in the signature to learn more about its function, potential to predict outcome, and immune system role. RT-PCR was performed to verify the true expression level of IL18. Results: A total of 136 DEGs associated with breast cancer responses to both immunity and lipid metabolism. Nine key genes (CALR, CCL5, CEPT, FTT3, CXCL13, FLT3, IL12B, IL18, and IL24, p \u003C 1.6e−2) of breast cancer were identified, and a prognostic was successfully constructed with a good predictive ability. IL18 in the model also had good clinical prognostic guidance value and immune regulation and therapeutic potential. Furthermore, the expression of IL18 was higher than that in paracancerous tissue.  \nConclusions: A unique predictive signature model could effectively predict the prognosis of breast cancer, which can not only achieve survival prediction, but also screen out key genes with important functional mechanisms to guide clinical drug experiments.  \nINTRODUCTION  \nIn recent years, breast cancer has eclipsed lung cancer asa major health threat to women. Malignant breast cancers  \nform in the ductal and lobular areas [1, 2] . Recently, more than 20% of newly diagnosed cancers in Chinese women are breast cancer [3] . The primary clinical intervention among them continues to be pharma-  \n8611  \ncological therapy, and with the introduction of immunomodulatory drug therapy, the treatment resources have significantl","cbCaihPTZyQOGbYh","https://ap.wps.com/l/cbCaihPTZyQOGbYh","pdf",2681204,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What is the main purpose of constructing the novel gene signature?\",\"answer\":\"To predict breast cancer prognosis and provide functional insight by linking lipid metabolism-related and immune-related gene activity to clinical outcomes.\"},{\"question\":\"How was the predictive signature built and validated?\",\"answer\":\"Differentially expressed genes were obtained from UCSC, lipid metabolism and immune-related genes were gathered from GSEA and immune resources, and a signature was constructed using univariate Cox and LASSO regression, then assessed with Kaplan-Meier and time-dependent ROC plus survival risk scoring.\"},{\"question\":\"Which key gene is highlighted, and why?\",\"answer\":\"IL18 is emphasized because it had not been previously reported in breast cancer within the context of the study’s signature, and it is used to explore function, outcome prediction potential, and immune-system involvement.\"}]","A novel signature incorporating genes related to lipid metabolism and immune for prognostic and functional prediction of breast cancer | PDF",1790002428,48]