[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-430723-105":59,"doc-detail-430723-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","a-novel-predictor-of-short-term-prognosis-in-acute-pulmonary-embolism-inflammatory-burden-index","A novel predictor of short-term prognosis in acute pulmonary embolism - inflammatory burden index","","Inflammation substantially influences disease progression and short-term outcomes in acute pulmonary embolism (APE), yet the most effective way to quantify inflammatory activity for prognosis remained unclear. This retrospective study assessed nine blood-based inflammatory markers in 301 APE patients, comparing their ability to predict 30-day mortality against the standard sPESI score. Higher inflammatory burden index (IBI) showed a strong, independent, linear association with increased 30-day death risk, outperforming all other markers. IBI can be calculated from routine blood tests (CRP, neutrophils, lymphocytes) and may improve early risk stratification and support individualized treatment decisions.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-novel-predictor-of-short-term-prognosis-in-acute-pulmonary-embolism-inflammatory-burden-index/430723/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-novel-predictor-of-short-term-prognosis-in-acute-pulmonary-embolism-inflammatory-burden-index/430723.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main goal of this study in APE patients?","Question",{"text":112,"@type":113},"To identify the most effective blood-based inflammatory marker for predicting short-term mortality in patients with acute pulmonary embolism.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the inflammatory burden index (IBI) evaluated?",{"text":117,"@type":113},"The study retrospectively analyzed 301 APE patients and compared the predictive performance of nine inflammatory markers for 30-day mortality, with emphasis on IBI versus the standard sPESI score.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the results show about IBI and 30-day mortality?",{"text":121,"@type":113},"After adjustment for potential confounders, higher IBI was strongly and independently associated with increased 30-day mortality risk, with superior predictive ability and a linear risk relationship.",{"name":123,"@type":110,"acceptedAnswer":124},"How is IBI calculated and why is it clinically useful?",{"text":125,"@type":113},"IBI is calculated from routine blood tests including C-reactive protein and counts of neutrophils and lymphocytes, offering a simple, rapid, and cost-effective tool for early risk stratification; external validation is still needed.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},430723,1790877377,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":36,"preview_page_count":4},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TherapeuTic advances in cardiovascular disease  \nOriginal Research  \n\n| A novel predictor of short-term prognosis in acute pulmonary embolism: inflammatory burden index\u003Cbr>Lingwei Huang, Dan Xiao, Meimei Yang, Zixing Wu and Fei He\u003Cbr>Abstract\u003Cbr>Background: Inflammation significantly impacts disease progression and prognosis in acute pulmonary embolism (APE); however, the optimal method to quantify this inflammation for prognostic purposes remains unclear.\u003Cbr>Objectives: We aimed to identify the most effective blood-based inflammatory marker for predicting short-term mortality in patients with APE.\u003Cbr>Methods: We retrospectively analyzed 301 patients with APE. We compared the predictive performance of nine inflammatory markers for 30-day mortality, focusing on the inflammatory burden index (IBI), and contrasted it with the standard clinical score (sPESI) .\u003Cbr>Results: After adjusting for potential confounders, a higher IBI was strongly and independently associated with an increased risk of 30-day mortality. IBI demonstrated superior predictive ability compared with all other inflammatory markers and the sPESI score. The relationship between IBI and mortality risk was linear; higher IBI values corresponded to greater mortality risk.\u003Cbr>Conclusion: IBI is a robust and independent predictor of short-term survival in patients with APE. Calculated from routine blood tests (C-reactive protein, neutrophil, and lymphocyte counts), it offers a simple, rapid, and cost-effective tool that may enhance early risk stratification and guide personalized treatment decisions in clinical practice. Further validation in independent cohorts is required to confirm its prognostic utility.\u003Cbr>Keywords: acute pulmonary embolism (APE), biomarkers, inflammations, inflammatory burden index (IBI), short-term prognosis, simplified pulmonary embolism severity index (sPESI)\u003Cbr>Received: 25 May 2025; revised manuscript accepted: 17 November 2025. |  | TherAdv Cardiovasc Dis 2026, Vol. 20: 1–16\u003Cbr>DOI: 10. 1177/\u003Cbr>17539447251407467 © The Author(s), 2026. Article reuse guidelines:\u003Cbr>[sagepub.com/journals](sagepub.com/journals)permissions\u003Cbr>Correspondence to:\u003Cbr>Fei He\u003Cbr>Department of Geriatrics, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing 402160, China\u003Cbr>Chongqing Municipality Clinical Research Center for Geriatric Diseases (Yongchuan Hospital, Chongqing Medical University), Chongqing 402160, China\u003Cbr>[hefeicqums@sina.com](hefeicqums@sina.com)\u003Cbr>Lingwei Huang\u003Cbr>Department of Geriatrics, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China\u003Cbr>Chongqing Municipality Clinical Research Center for Geriatric Diseases (Yongchuan Hospital, Chongqing Medical University), Yongchuan, Chongqing, China\u003Cbr>Dan Xiao\u003Cbr>Department of Internal Medicine, Sichuan University Hospital, Sichuan University, Chengdu, Sichuan, China\u003Cbr>Meimei Yang\u003Cbr>Department of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan, China\u003Cbr>Zixing Wu\u003Cbr>Chongqing Municipality Clinical Research Center for Geriatric Diseases (Yongchuan Hospital, Chongqing Medical University), Yongchuan, Chongqing, China Department of General Practice, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China |\n| --- | --- | --- |\n| Introduction\u003Cbr>Acute pulmonary embolism (APE) is a life-threatening cardiovascular emergency associated with high mortality, particularly within the first 30 days after onset.1–3 Accurate prognostic assessment is essential for the identification of high-risk patients. Although current guideline-recommended tools that rely on imaging, laboratory tests, and various scoring systems are valuable, they are often complex and resource-intensive, underscoring the need for simpler and more costeffective prognostic indices.4,5 | Systemic inflammation plays a key role in the pathophysiology and progression of APE.6–9 This observation has prompted g","cbCairBawYOBH6IX","https://ap.wps.com/l/cbCairBawYOBH6IX","pdf",1921028,16,"English","# Abstract\n## Background\n## Objectives\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Need for simpler prognostic indices\n## Role of inflammation in APE\n## Inflammatory biomarkers and composite indices","[{\"question\":\"What is the main goal of this study in APE patients?\",\"answer\":\"To identify the most effective blood-based inflammatory marker for predicting short-term mortality in patients with acute pulmonary embolism.\"},{\"question\":\"How was the inflammatory burden index (IBI) evaluated?\",\"answer\":\"The study retrospectively analyzed 301 APE patients and compared the predictive performance of nine inflammatory markers for 30-day mortality, with emphasis on IBI versus the standard sPESI score.\"},{\"question\":\"What do the results show about IBI and 30-day mortality?\",\"answer\":\"After adjustment for potential confounders, higher IBI was strongly and independently associated with increased 30-day mortality risk, with superior predictive ability and a linear risk relationship.\"},{\"question\":\"How is IBI calculated and why is it clinically useful?\",\"answer\":\"IBI is calculated from routine blood tests including C-reactive protein and counts of neutrophils and lymphocytes, offering a simple, rapid, and cost-effective tool for early risk stratification; external validation is still needed.\"}]","A novel predictor of short-term prognosis in acute pulmonary embolism - inflammatory burden index | PDF",1790653536]