[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-457309-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-457309-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","a-novel-computed-tomography-based-algorithm-for-the-quantitative-identification-of-lumbar-spine-localized-trabecular-bone-loss-in-patients-with-type-2-diabetes-mellitus","A novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus","","A novel quantitative computed tomography (CT) algorithm was applied to evaluate lumbar spine-localized trabecular bone loss (LTBL) and determine how it relates to type 2 diabetes mellitus (T2DM). The study retrospectively enrolled 166 participants, including 94 with T2DM and 72 without T2DM, using quantitative CT to measure lumbar spine BMD. LTBL was defined by trabecular regions with BMD \u003C40 mg/cm3 and volume ≥16.5 mm3, and groups were compared using Mann-Whitney, with correlations assessed by Spearman and factors by regression.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-novel-computed-tomography-based-algorithm-for-the-quantitative-identification-of-lumbar-spine-localized-trabecular-bone-loss-in-patients-with-type-2-diabetes-mellitus/457309/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-novel-computed-tomography-based-algorithm-for-the-quantitative-identification-of-lumbar-spine-localized-trabecular-bone-loss-in-patients-with-type-2-diabetes-mellitus/457309.png","ImageObject",300,407,{"name":42,"@type":43},"Terk","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is bone mineral density (BMD) insufficient for assessing diabetic bone health?","Question",{"text":63,"@type":64},"Conventional assessments based on average BMD cannot capture localized trabecular abnormalities, and in T2DM patients BMD may be unchanged or even increased despite higher fracture risk. BMD also explains only part of the variability in bone health.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was lumbar spine-localized trabecular bone loss (LTBL) quantified?",{"text":68,"@type":64},"Lumbar spine BMD was measured using quantitative CT (QCT). LTBL was quantified with a novel algorithm and defined as trabecular regions with BMD \u003C40 mg/cm3 and volume ≥16.5 mm3, recording the number and volume of LTBL areas.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings regarding LTBL in T2DM versus non-T2DM groups?",{"text":72,"@type":64},"The T2DM group showed more severe LTBL, including a higher total number of LTBL areas, more vertebrae with LTBL, and greater total LTBL volume, despite BMD being slightly higher without significant differences. The effect of T2DM on LTBL was independent of age and BMD.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},457309,1790795834,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Original Article  \nA novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus  \nJiaxin Chen1\\#, Jiangyuan Pi2\\#, Runmeng Li1, Kai Huang1, Jun Gao1, Chaojun Zhao1, Yi Ma1, Zhenguang Zhang1, Yilong Huang1  \n1Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming, China; 2Graduate School, Kunming Medical University, Kunming, China  \nContributions: (I) Conception and design: Z Zhang, Y Huang, J Chen; (II) Administrative support: J Pi, Z Zhang; (III) Provision of study materials or patients: J Chen, R Li; (IV) Collection and assembly of data: J Pi, K Huang, J Gao, C Zhao, Y Ma; (V) Data analysis and interpretation: Y Huang, J Chen; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \n\\#These authors contributed equally to this work as co-first authors.  \nCorrespondence to: Zhenguang Zhang, MM; Yilong Huang, MD. Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical  \nUniversity, No. 295 Xichang Rd., Kunming 650032, China. Email: [178546941@qq.com](178546941@qq.com); [kmhuangyilong@qq.com](kmhuangyilong@qq.com).  \nBackground: Conventional bone health assessment based on average bone mineral density (BMD) cannot capture localized trabecular abnormalities, and BMD is not always decreased in patients with type 2 diabetes mellitus (T2DM) . To overcome these limitations of using BMD alone in diagnosis, this study aimed to apply a novel computed tomography (CT)-based algorithm to quantitatively evaluate lumbar spine-localized  \ntrabecular bone loss (LTBL) in individuals with and without T2DM.  \nMethods: This study retrospectively enrolled individuals with and without T2DM, and their basic clinical information was collected. Lumbar spine BMD was measured via quantitative CT (QCT) . LTBL was quantified via a novel algorithm, with LTBL defined as trabecular regions with BMD \u003C40 mg/cm3 and volume ≥ 16.5 mm3. Parameters of LTBL, including the number and volume of LTBL areas, were recorded.  \nMann-Whitney tests were used to compare BMD and LTBL parameters between the T2DM and nonT2DM groups. Spearman correlation analysis was conducted to assess the relationships between age, BMD, and LTBL parameters. Regression analysis was used to evaluate factors influencing LTBL. All statistics are  \nexpressed in terms of median and interquartile range.  \nResults: A total of 166 participants were included, comprising 94 with T2DM and 72 without T2DM.  \nThe T2DM group had a slightly higher BMD than did the non-T2DM group (P>0.05) . The T2DM group, as compared to the non-T2DM group, had a significantly higher total number of LTBL areas [12.00 (8.00, 24.00) vs. 10.00 (5 .00, 16. 50), P\u003C0 .05], number of vertebrae with LTBL [5 .00 (4 .00, 5.00) vs. 4.00 (3 .00, 5.00), P\u003C0 .05], and total volume of LTBL areas [576 .00 (303 .00, 1,276 .00) vs. 448.50 (199 .00, 853. 50) mm3, P\u003C0.05] . There was a slight positive correlation between age and total number (r=0.35; P\u003C0.05) and volume (r=0.33; P\u003C0.05) of LTBL areas in the T2DM group. BMD was moderately negatively correlated with both the total number (r=−0.47; P\u003C0.05) and volume of LTBL areas in the T2DM group (r=−0.47; P\u003C0.05) .  \nRegression analysis showed that age was positively associated with the total number of LTBL areas (β=0.336;  \nP\u003C0.05), total volume of LTBL areas (β=34.778, P\u003C0.05), and number of vertebrae with LTBL (β=0.019;  \nP\u003C0.05); meanwhile, BMD was negatively associated with these parameters (β=−0.252, β=−14.778, and β=−0.014, respectively; P\u003C0.05), while T2DM was positively associated (β=6.222, β=497.558, and β=0.533, respectively; P\u003C0.05) . In contrast, gender and BMI showed no significant associations with any of these  \n© AME Publishing Company. Quant Imaging Med Surg 2026;16(1):34 | [https://dx.doi.org/10.21037/qims-2025-1312](https://dx.doi.org/10.21037/qims-2025-1312)  \nPage 2 of 14","cbCaiq0NgLIUbcXQ","https://ap.wps.com/l/cbCaiq0NgLIUbcXQ","pdf",2724766,14,"English","# Background\n# Methods\n# Results\n# Conclusions\n# Keywords\n# Publication Information\n# Introduction","[{\"question\":\"Why is bone mineral density (BMD) insufficient for assessing diabetic bone health?\",\"answer\":\"Conventional assessments based on average BMD cannot capture localized trabecular abnormalities, and in T2DM patients BMD may be unchanged or even increased despite higher fracture risk. BMD also explains only part of the variability in bone health.\"},{\"question\":\"How was lumbar spine-localized trabecular bone loss (LTBL) quantified?\",\"answer\":\"Lumbar spine BMD was measured using quantitative CT (QCT). LTBL was quantified with a novel algorithm and defined as trabecular regions with BMD \\u003c40 mg/cm3 and volume ≥16.5 mm3, recording the number and volume of LTBL areas.\"},{\"question\":\"What were the main findings regarding LTBL in T2DM versus non-T2DM groups?\",\"answer\":\"The T2DM group showed more severe LTBL, including a higher total number of LTBL areas, more vertebrae with LTBL, and greater total LTBL volume, despite BMD being slightly higher without significant differences. The effect of T2DM on LTBL was independent of age and BMD.\"}]","A novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus | PDF",1790748839,35]