[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373643-105":59,"doc-detail-373643-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","a-nomogram-for-predicting-noncurative-resection-in-patients-with-early-gastric-cancer-based-on-white-light-imaging-research","A nomogram for predicting noncurative resection in patients with early gastric cancer based on white light imaging - Research","","Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric cancer, but non-curative resection (NCR) can still necessitate additional surgery. A retrospective cohort of 568 early gastric cancer patients undergoing ESD between March 2016 and March 2024 was analyzed using white light imaging (WLI) and clinicopathological factors. A nomogram built on 455 training cases identified independent WLI predictors, including marked redness, ulceration, fold convergence, marginal elevation, whitish mucosal change, larger lesions, and Helicobacter pylori infection. The model demonstrated predictive performance with AUCs of 0.8095 (training) and 0.7567 (validation).",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-nomogram-for-predicting-noncurative-resection-in-patients-with-early-gastric-cancer-based-on-white-light-imaging-research/373643/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-nomogram-for-predicting-noncurative-resection-in-patients-with-early-gastric-cancer-based-on-white-light-imaging-research/373643.png","ImageObject",300,407,{"name":92,"@type":93},"Mabel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose of the nomogram in this study?","Question",{"text":113,"@type":114},"To predict the risk of non-curative resection (NCR) before ESD by using white light imaging (WLI) features and related clinical/pathological factors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients divided into training and validation sets?",{"text":118,"@type":114},"Patients undergoing ESD before March 2023 were used as the training set, and those treated afterward formed the validation set, based on March 2023 as the cutoff.",{"name":120,"@type":111,"acceptedAnswer":121},"Which white light imaging features were associated with independent risk factors for NCR?",{"text":122,"@type":114},"Features including remarkable redness, ulceration, fold convergence, marginal elevation, whitish mucosal change, larger lesions, and Helicobacter pylori (Hp) infection were linked to independent NCR risk.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},373643,1790533238,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},7971474920318,"https://ap-avatar.wpscdn.com/avatar/74000ee537e6b0ca360?x-image-process=image/resize,m_fixed,w_180,h_180&k=1788430171632181674","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nA nomogram for predicting noncurative resection in patients with early gastric cancer based on white light imaging  \nMengyu Cao, Linlin Ren, Congcong Min, Zeyuan Diao, HaoChen, Hua Liu, Xiaoyu Li, Jiahui Xu, Zibin Tian & Tao Mao􀀍  \nEndoscopic submucosal dissection (ESD) is an effective treatment with minimal invasiveness for early gastric cancer (EGC). However, cases undergoing non-curative resection (NCR) may still undergo additional surgical procedures. We aimed to analyze the features of NCR under white light imaging (WLI), and develop a prediction model to assess the risk of NCR before ESD. We retrospectively collected and analyzed WLI and clinicopathological features of 568 EGC patients undergoing ESD between March 2016 and March 2024. A nomogram was developed on 455 patients from the training set after subgroup difference analysis. 91 out of 568 (16.0%) cases had NCR. WLI features including remarkable redness, ulceration, fold convergence, marginal elevation, whitish mucosal change, larger lesions, and Helicobacter pylori (Hp) infection were associated with independent risk factors for NCR. The nomogram based on these features showed good predictive value for NCR, with an area under the curve (AUC) of 0.8095 (95% CI: 0.7538–0.8651) in the training set and 0.7567 (95% CI: 0.6427–0.8707) in the validation set. We developed a nomogram incorporating WLI features that exhibits good predictive performance and could potentially assist in selecting optimal treatment strategies for EGC.  \nKeywords Early gastric cancer, Non-curative resection, Endoscopic submucosal dissection, White light imaging, Nomogram  \nEarly gastric cancer (EGC) refers to gastric cancer that is limited to the mucosa or submucosa, regardless of lymph node metastasis, for which the optimal treatment method currently is endoscopic submucosal dissection (ESD)1,2. ESD triumphs over traditional surgical intervention by offering minimal trauma, shorter recovery time, fewer complications, and reduced economic burdens, with a 5-year overall survival (OS) rate exceeding 90% for most cases3. Nevertheless, non-curative resection (NCR) still remains as a major caveat for ESD, affecting up to 30–40% of patients undergoing ESD. NCR poses potential risk for local recurrence and lymph node metastasis (LNM) that subsequently require surgical resection4.Hence, accurate pre-procedural prediction could facilitate risk evaluation and optimal treatment selection for EGC patients.  \nThe continuous advancement of endoscopic techniques has significantly enhanced the detection and diagnostic capabilities for gastric lesions. Currently, widely used techniques include white light imaging (WLI), magnifying endoscopy, and endoscopic ultrasound5. Magnifying endoscopy can determine whether a lesion is neoplastic, but it cannot assess the depth of invasion. Factors such as lesions located in the upper third of the stomach, excessively large lesion diameter, and low differentiation grade can all affect the accuracy of endoscopic ultrasound evaluation. WLI is currently the most prevalent procedure for detecting abnormalities and evaluating mucosal status in the gastrointestinal tract worldwide. It enables physicians to identify early signs of cancerous lesions, such as ulceration, redness, elevated margins, and fold convergence6,7, at a manageable cost for most patients. Endoscopic features, along with other parameters such as pathology type, depth of infiltration, and inflammation indices including systemic immune inflammation index (NLR) and neutrophil–lymphocyte ratio (SII)8–12, have been utilized for constructing prediction models for NCR. Unfortunately, these models either lack adequate validation on a different cohort or fall short of comprehensively including WLI features for EGC. Herein, we aim to describe the pre-procedural WLI features of EGC patients in a Chinese cohort and analyze their capacity for pre","cbCaioiLHjBkwWfU","https://ap.wps.com/l/cbCaioiLHjBkwWfU","pdf",1891060,"English","# Methods\n## Patient selection\n## Data collection","[{\"question\":\"What is the purpose of the nomogram in this study?\",\"answer\":\"To predict the risk of non-curative resection (NCR) before ESD by using white light imaging (WLI) features and related clinical/pathological factors.\"},{\"question\":\"How were patients divided into training and validation sets?\",\"answer\":\"Patients undergoing ESD before March 2023 were used as the training set, and those treated afterward formed the validation set, based on March 2023 as the cutoff.\"},{\"question\":\"Which white light imaging features were associated with independent risk factors for NCR?\",\"answer\":\"Features including remarkable redness, ulceration, fold convergence, marginal elevation, whitish mucosal change, larger lesions, and Helicobacter pylori (Hp) infection were linked to independent NCR risk.\"}]","A nomogram for predicting noncurative resection in patients with early gastric cancer based on white light imaging - Research | PDF",1790200104,28]