[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339275-105":59,"doc-detail-339275-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-new-perspective-on-prostate-cancer-treatment-the-interplay-between-cellular-senescence-and-treatment-resistance","A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance","","Resistance to prostate cancer (PCa) treatment—especially to androgen deprivation therapy (ADT)—creates a major obstacle in PCa management. Radiotherapy, chemotherapy, and hormone therapy can induce apoptosis but may also activate stress-induced premature senescence (SIPS). Senescent tumor cells show dual effects: growth arrest and reduced tumor proliferation on one side, but secretion of cytokines, growth factors, and proteases that can harm treatment efficacy on the other. This review analyzes how SIPS is triggered and how senescent cells influence therapy outcomes, aiming to inform novel strategies to overcome treatment resistance and improve patient outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-new-perspective-on-prostate-cancer-treatment-the-interplay-between-cellular-senescence-and-treatment-resistance/339275/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-new-perspective-on-prostate-cancer-treatment-the-interplay-between-cellular-senescence-and-treatment-resistance/339275.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":56},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the review focus on in prostate cancer treatment?","Question",{"text":112,"@type":113},"The review focuses on how resistance to prostate cancer therapies—particularly androgen deprivation therapy (ADT)—limits effective management.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do therapies like radiotherapy, chemotherapy, and hormone therapy relate to SIPS?",{"text":117,"@type":113},"These therapies can induce stress-induced premature senescence (SIPS), alongside apoptosis in tumor cells.",{"name":119,"@type":110,"acceptedAnswer":120},"Why can cellular senescence have both beneficial and harmful effects in treatment?",{"text":121,"@type":113},"Senescent tumor cells can withdraw from the cell cycle, slowing tumor growth, but they can also secrete factors that influence neighboring tumor cells and worsen treatment outcomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},339275,1790037365,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":56,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","TYPE Review  \nPUBLISHED 17 April 2024  \nDOI 10.3389/fimmu.2024.1395047  \nOPEN ACCESS  \nEDITED BY  \nDechao Feng,  \nUniversity College London, United Kingdom  \nREVIEWED BY Bin Xu,  \nRenmin Hospital of Wuhan University, China Yingkun Xu,  \nChongqing Medical University, China  \n*CORRESPONDENCE Shao-Gang Wang  \n [sgwangtjm@163.com](sgwangtjm@163.com)[ ](sgwangtjm@163.com)Qi-Dong Xia  \n [qidongxia_md@163.com](qidongxia_md@163.com)  \n†These authors have contributed equally to this work and share first authorship  \n‡These authors have contributed equally to this work  \nRECEIVED 03 March 2024  \nACCEPTED 01 April 2024  \nPUBLISHED 17 April 2024  \nCITATION  \nXu M-Y, Xia Z-Y, Sun J-X, Liu C-Q, An Y, Xu J-Z, Zhang S-H, Zhong X-Y, Zeng N, Ma S-Y, He H-D, Wang S-G and Xia Q-D (2024) A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance.  \nFront. Immunol. 15:1395047 .  \ndoi: 10.3389/fimmu.2024.1395047  \nCOPYRIGHT  \n© 2024 Xu, Xia, Sun, Liu, An, Xu, Zhang, Zhong, Zeng, Ma, He, Wang and Xia. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nA new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance  \nMeng-Yao Xu †, Zhi-Yu Xia †, Jian-Xuan Sun, Chen-Qian Liu, Ye An, Jin-Zhou Xu, Si-Han Zhang, Xing-Yu Zhong, Na Zeng, Si-Yang Ma, Hao-Dong He, Shao-Gang Wang*‡  \nand Qi-Dong Xia*‡  \nDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China  \nThe emergence of resistance to prostate cancer (PCa) treatment, particularly to androgen deprivation therapy (ADT), has posed a significant challenge in the field of PCa management. Among the therapeutic options for PCa, radiotherapy, chemotherapy, and hormone therapy are commonly used modalities. However, these therapeutic approaches, while inducing apoptosis in tumor cells, may also trigger stress-induced premature senescence (SIPS) . Cellular senescence, an entropy-driven transition from an ordered to a disordered state, ultimately leading to cell growth arrest, exhibits a dual role in PCa treatment. On one hand, senescent tumor cells may withdraw from the cell cycle, thereby reducing tumor growth rate and exerting a positive effect on treatment. On the other hand, senescent tumor cells may secrete a plethora of cytokines, growth factors and proteases that can affect neighboring tumor cells, thereby exerting a negative impact on treatment. This review explores how radiotherapy, chemotherapy, and hormone therapy trigger SIPS and the nuanced impact of senescent tumor cells on PCa treatment. Additionally, we aim to identify novel therapeutic strategies to overcome resistance in PCa treatment, thereby enhancing patient outcomes.  \nKEYWORDS  \ncellular senescence, drug resistance, treatment resistance, prostate cancer, SIPS  \nAbbreviations: PCa, Prostate cancer; EAU, European Association of Urology; PSA, Prostate-specific antigen; GS, Gleason score; AS, Active surveillance; CRPC, Castration-resistant prostate cancer; CSCs, Cancer stem cells; TCP, Tumor cell plasticity; TME, Tumor microenvironment; EMT, Epithelial-to-mesenchymal transition; DTP, Drug-tolerant persister; ROS, Reactive oxygen species; SIPS, Stress-induced premature senescence; ECM, Extracellular matrix; SA-b-Gal, Senescence-associated b-galactosidase; SAHF, Senescenceassociated heterochromatin foci; SASP, Senescence-associated secretory phenotype; Cdk, Cyclin-dependent protein kinase; ADT, Androgen deprivation therapy; TIS, Therapy-induced senescence; LHRH, Luteinizing hormone-releas","cbCaicxKZNamslxV","https://ap.wps.com/l/cbCaicxKZNamslxV","pdf",3076302,14,"English","# Introduction\n## Treatment options and the challenge of resistance\n## Primary vs secondary treatment resistance\n# Stress-induced premature senescence (SIPS)\n## Dual roles of senescent tumor cells\n# Triggers of SIPS across therapies\n## Radiotherapy-induced SIPS\n## Chemotherapy-induced SIPS\n## Hormone therapy-induced SIPS\n# Therapeutic implications and overcoming resistance","[{\"question\":\"What problem does the review focus on in prostate cancer treatment?\",\"answer\":\"The review focuses on how resistance to prostate cancer therapies—particularly androgen deprivation therapy (ADT)—limits effective management.\"},{\"question\":\"How do therapies like radiotherapy, chemotherapy, and hormone therapy relate to SIPS?\",\"answer\":\"These therapies can induce stress-induced premature senescence (SIPS), alongside apoptosis in tumor cells.\"},{\"question\":\"Why can cellular senescence have both beneficial and harmful effects in treatment?\",\"answer\":\"Senescent tumor cells can withdraw from the cell cycle, slowing tumor growth, but they can also secrete factors that influence neighboring tumor cells and worsen treatment outcomes.\"}]","A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance | PDF",1790029122,35]