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Patients with head and neck squamous cell carcinoma (SCC) face increased risk of additional malignancies, making treatment planning complex. This report describes a 61-year-old man with keratinizing SCC of the lower lip and metastatic papillary thyroid carcinoma (PTC). He received partial lip resection, neck dissection, total thyroidectomy, adjuvant radiotherapy (66 Gy/33 fractions) for SCC, and radioiodine therapy (131-I) for PTC.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-multidisciplinary-approach-for-a-patient-with-synchronous-lip-and-thyroid-cancer-involving-radiotherapy/354075/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-multidisciplinary-approach-for-a-patient-with-synchronous-lip-and-thyroid-cancer-involving-radiotherapy/354075.png","ImageObject",300,407,{"name":92,"@type":93},"วิน","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How are synchronous cancers defined in this report?","Question",{"text":112,"@type":113},"They are malignant tumors detected concurrently or within a two-month interval following the initial neoplastic diagnosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the two cancer diagnoses in the 61-year-old patient?",{"text":117,"@type":113},"The patient had keratinizing squamous cell carcinoma of the lower lip and papillary thyroid carcinoma with metastatic findings.",{"name":119,"@type":110,"acceptedAnswer":120},"What combined treatments were used after surgery?",{"text":121,"@type":113},"The patient underwent adjuvant conventional radiotherapy for SCC and radioiodine therapy (131-I) for PTC, following complete surgical management including neck dissection and total thyroidectomy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},354075,1790628554,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","Cancer Reports  \nCASE REPORT  OPEN ACCESS   \nA Multidisciplinary Approach for  \na Patient With Synchronous Lip and Thyroid Cancer Involving Radiotherapy  \nAleksandra Nasiek1  | Paweł Polanowski1  | Marek Hamm2  | Anna Kozub3  | Barbara Lipka4  | Agnieszka Kotecka-Blicharz2  | Krzysztof Składowski1   \n11st Radiation and Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland | 2Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland | 33rd Radiation and Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland | 4Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland  \nCorrespondence: Aleksandra Nasiek ([ola.nasiek@gmail.com](ola.nasiek@gmail.com))  \nReceived: 8 July 2025 | Revised: 20 April 2026 | Accepted: 22 April 2026  \nKeywords: head and neck region | papillary thyroid carcinoma | squamous cell carcinoma | synchronous cancers  \nABSTRACT  \nBackground: Synchronous cancers, defined as malignancies diagnosed concurrently or within 2 months of each other, are rare, with an incidence of 1%–6%. Environmental factors such as tobacco smoking play a significant role in their development. Patients with head and neck squamous cell carcinoma (SCC) are at increased risk of second malignancies, complicating treatment strategies and prognosis. This report presents a rare case of synchronous SCC of the lower lip and papillary thyroid carcinoma (PTC) . Case: A 61-year-old male with a history of smoking presented with a 2.5 cm exophytic lesion of the lower lip, diagnosed as keratinizing SCC. A suspicious cervical lymph node was revealed, which intraoperatively demonstrated metastatic PTC. Following partial lip resection and neck dissection, total thyroidectomy was performed, confirming a 1.5 mm PTC focus with micrometastases. The patient underwent adjuvant conventional radiotherapy (RTH) for SCC (66 Gy in 33 fractions) and radioiodine therapy (131-I) for PTC. Post-therapeutic scintigraphy identified suspected micrometastases in the iliac bone, prompting further 131-I treatment. Following completion of therapy, the patient achieved a complete response, with no radiologic or clinical evidence of residual disease from both malignancies.  \nConclusion: Synchronous SCC of the lip and PTC are exceedingly rare, lacking standardized treatment guidelines. This case highlights the necessity of a multidisciplinary approach, integrating surgery, RTH, and systemic therapy. Careful postoperative histopathological assessment of lymph nodes may reveal unexpected findings that necessitate further diagnostic work-up and a multidisciplinary approach, as this can significantly influence staging, treatment decisions, and patient prognosis, representing an important key learning point.  \n1 | Introduction  \nSynchronous cancers are defined as malignant tumors detected concurrently or within a two-month interval following the initial neoplastic diagnosis. Typically, they are rare, with an incidence ranging from 1% to 6% . Environmental factors including  \ntobacco smoking are one of the main risk factors [1] . Patients with squamous cell carcinoma (SCC) of the head and neck represent an increased risk of developing a second malignancy, which significantly affects their diagnostic process, treatment strategies, and overall survival. Synchronous cancers usually are identified during the initial diagnosis of a primary tumor;  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Cancer Reports published by Wiley Periodicals LLC.  \nCancer Reports, 2026; 9:e70564 1 of 5  \n[https://doi.org/10.1002/cnr2.70564](https://doi.org/10.100","cbCaicz11pI3a3t3","https://ap.wps.com/l/cbCaicz11pI3a3t3","pdf",398410,"English","# Abstract\n## Background\n## Case\n## Conclusion\n# Introduction\n# Case Presentation","[{\"question\":\"How are synchronous cancers defined in this report?\",\"answer\":\"They are malignant tumors detected concurrently or within a two-month interval following the initial neoplastic diagnosis.\"},{\"question\":\"What were the two cancer diagnoses in the 61-year-old patient?\",\"answer\":\"The patient had keratinizing squamous cell carcinoma of the lower lip and papillary thyroid carcinoma with metastatic findings.\"},{\"question\":\"What combined treatments were used after surgery?\",\"answer\":\"The patient underwent adjuvant conventional radiotherapy for SCC and radioiodine therapy (131-I) for PTC, following complete surgical management including neck dissection and total thyroidectomy.\"}]","A Multidisciplinary Approach for a Patient With Synchronous Lip and Thyroid Cancer Involving Radiotherapy | PDF",1790108758,13]