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Laparoscopic appendectomy (LA) has been reported to carry higher fetal loss rates than open appendectomy (OA), prompting reassessment. This multicenter Japanese study retrospectively evaluated 152 pregnant patients treated for acute appendicitis from 2012–2021, comparing OA (n=92) and LA (n=60) with fetal loss during hospitalization as the primary endpoint.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-multicenter-collaborative-study-on-the-safety-and-efficacy-of-laparoscopic-appendectomy-during-pregnancy/413523/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-multicenter-collaborative-study-on-the-safety-and-efficacy-of-laparoscopic-appendectomy-during-pregnancy/413523.png","ImageObject",300,407,{"name":92,"@type":93},"pixelkiddo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main purpose of the study?","Question",{"text":113,"@type":114},"To evaluate the safety and efficacy of laparoscopic appendectomy in pregnant women with acute appendicitis in current Japanese practice.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients grouped in the analysis?",{"text":118,"@type":114},"Patients were retrospectively reviewed and divided into OA (n=92) and LA (n=60) groups based on the surgical approach.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key findings regarding fetal loss and hospital stay?",{"text":122,"@type":114},"No fetal loss occurred in either group. Hospital stay was significantly shorter in the LA group than in the OA group, while operative time and postoperative complications were similar.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},413523,1790719381,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090883892,"https://ap-avatar.wpscdn.com/avatar/e00115db34f3e0f11b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1790152879550218658","Annals of  \nGastroenterological Surgery  \nORIGINAL ARTICLE  OPEN ACCESS   \nA Multicenter Collaborative Study on the Safety and  \nEfficacy of Laparoscopic Appendectomy During Pregnancy  \nKatsuhiro Ogawa1  | Tomonori Akagi1  | Hidefumi Shiroshita1  | Hiroshi Yoshida2 | Masashi Miguchi3 | Ken Eto4 | Tetsuji Ohyama5 | Akiyoshi Kanazawa6 | Keiji Matsuda7 | Koya Hida8  | Seiichiro Yamamoto9  |  \nTakeshi Naitoh10  | Masafumi Inomata1 | Japan Society of Laparoscopic Colorectal Surgery  \n1Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan | 2Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan | 3Department of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan | 4Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan | 5Biostatistics Center, Kurume University, Fukuoka, Japan | 6Department of Surgery, Shimane Prefectural Central Hospital, Izumo, Japan | 7The Fraternity Memorial Hospital, Department of Surgery, Tokyo, Japan | 8Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan | 9Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan | 10Department of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan  \nCorrespondence: Tomonori Akagi ([tomakagi@oita-u.ac.jp](tomakagi@oita-u.ac.jp))  \nReceived: 8 July 2025 | Revised: 7 August 2025 | Accepted: 26 August 2025  \nFunding: This study received funding from the Japan Society of Laparoscopic Colorectal Surgery (JSLCS 22-01). The funding source had no role in the design, practice, or analysis of this study.  \nKeywords: acute appendicitis | fetal loss | laparoscopic appendectomy | open appendectomy | pregnant  \nABSTRACT  \nAim: Acute appendicitis in pregnant women requires accurate diagnosis and treatment because of potential pregnancy complications. Laparoscopic appendectomy (LA) has been associated with higher rates of fetal loss than open appendectomy (OA) . Therefore, we conducted the first multicenter collaborative analysis in Japan to evaluate the safety and efficacy of LA during pregnancy.  \nMethods: We retrospectively reviewed 152 pregnant women who underwent appendectomy for acute appendicitis between 2012 and 2021 using data from the Japan Society of Laparoscopic Colorectal Surgery. The patients were divided into the OA (n = 92) and LA (n = 60) groups. The primary endpoint was fetal loss during hospitalization. Patient demographics, perioperative outcomes, pathology, and pregnancy outcomes were analyzed.  \nResults: No fetal loss occurred in either group. The operative time (p = 0.485) and postoperative complications (p = 0.708) were similar between the groups. However, the hospital stay was significantly shorter in the LA group than in the OA group (p = 0.037) . The OA group had a higher rate of gangrenous or perforated appendicitis (p = 0.017) .  \nConclusions: LA is a safe alternative to OA in pregnant women, with no additional maternal complications and comparable fetal outcomes. LA does not negatively affect fetal health.  \n1 | Introduction  \nAcute appendicitis during pregnancy tends to progress to a severe condition, and once perforation and subsequent peritonitis occur, the risk of preterm labor or fetal demise increases  \nsignificantly [1] . Therefore, an accurate diagnosis and timely and appropriate treatment are essential. Several critical factors must be considered when surgical treatment is deemed necessary. These include the potential impact not only on the mother but also on the fetus, limited surgical field owing to the enlarged  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s). Annals of Gastroenterol","cbCaia4e6c3F7HIi","https://ap.wps.com/l/cbCaia4e6c3F7HIi","pdf",303967,"English","# Abstract\n## Aim\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the main purpose of the study?\",\"answer\":\"To evaluate the safety and efficacy of laparoscopic appendectomy in pregnant women with acute appendicitis in current Japanese practice.\"},{\"question\":\"How were patients grouped in the analysis?\",\"answer\":\"Patients were retrospectively reviewed and divided into OA (n=92) and LA (n=60) groups based on the surgical approach.\"},{\"question\":\"What were the key findings regarding fetal loss and hospital stay?\",\"answer\":\"No fetal loss occurred in either group. Hospital stay was significantly shorter in the LA group than in the OA group, while operative time and postoperative complications were similar.\"}]","A Multicenter Collaborative Study on the Safety and Efficacy of Laparoscopic Appendectomy During Pregnancy | PDF",1790595089,15]