[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-618921-105":59,"doc-detail-618921-en":124},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":117,"head_meta":119,"extra_data":121,"updated_unix":123},105,"en","a-haploid-genetic-screen-identifies-the-hops-complex-and-npc1-as-host-factors-for-filovirus-entry","A Haploid Genetic Screen Identifies the HOPS Complex and NPC1 as Host Factors for Filovirus Entry","","This research paper, published in Nature in 2011 by JE Carette et al., details a comprehensive study identifying essential host factors required for the entry of filoviruses into cells. By employing a haploid genetic screen, the authors isolated specific genes, notably those comprising the HOPS complex and the NPC1 protein, which are critical for viral infection processes. The document provides molecular evidence through graphical data, including chromosomal positioning of identified genes, cell infection assays, and protein expression analysis, validating these targets as key mediators in the viral life cycle. This work significantly advances the understanding of host-pathogen interactions and provides potential therapeutic targets for mitigating filoviral infections. The experimental results, illustrated through comparative viral infectivity profiles and gene knockout validation, offer robust insights into the cellular mechanisms exploited by filoviruses for successful host entry and pathogenesis.",{"@graph":69,"@context":116},[70,84,99],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-haploid-genetic-screen-identifies-the-hops-complex-and-npc1-as-host-factors-for-filovirus-entry/618921/",{"url":83,"name":65,"@type":85,"author":86,"headline":65,"publisher":89,"fileFormat":92,"inLanguage":63,"description":67,"dateModified":93,"datePublished":93,"encodingFormat":92,"isAccessibleForFree":94,"interactionStatistic":95},"DigitalDocument",{"name":87,"@type":88},"Ophelia","Person",{"url":74,"name":90,"@type":91},"DocShare","Organization","application/octet-stream","2026-10-20",true,{"@type":96,"interactionType":97,"userInteractionCount":4},"InteractionCounter",{"@type":98},"ViewAction",{"@type":100,"mainEntity":101},"FAQPage",[102,108,112],{"name":103,"@type":104,"acceptedAnswer":105},"What are the key host factors identified in the study?","Question",{"text":106,"@type":107},"The study identifies the HOPS complex and the protein NPC1 as essential host factors for filovirus entry.","Answer",{"name":109,"@type":104,"acceptedAnswer":110},"What methodology was used to discover these factors?",{"text":111,"@type":107},"The researchers utilized a haploid genetic screen to identify genes that are necessary for filoviral entry into host cells.",{"name":113,"@type":104,"acceptedAnswer":114},"Why are these findings significant for research?",{"text":115,"@type":107},"These findings are significant because they clarify the molecular mechanisms of filovirus entry, which provides potential targets for developing new antiviral therapies.","https://schema.org",{"og:url":83,"og:type":118,"og:title":65,"og:site_name":90,"og:description":67},"article",{"robots":120,"canonical":83},"index,follow",{"doc_id":122,"site_id":62},618921,1792461998,{"code":4,"msg":5,"data":125},{"doc_id":122,"user_id":126,"nickname":87,"user_avatar":127,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":128,"file_id":129,"file_url":130,"file_type":131,"file_size":132,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":133,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":134,"faqs":135,"seo_title":136,"seo_description":67,"update_tm":123,"read_time":81},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","JE Carette et al. Nature 000, 1-4 (2011) doi:10.1038/nature10348\nA haploid genetic screen identifies the HOPS complex\u000band NPC1 as host factors for filovirus entry.","cbCait9z2swOwrhq","https://ap.wps.com/l/cbCait9z2swOwrhq","ppt",541184,"English","# Genetic Screen Identification of Host Factors\n## Chromosomal Distribution of Identified Genes\n## Viral Entry Assays and Validation\n## Role of NPC1 and HOPS Complex in Infection","[{\"question\":\"What are the key host factors identified in the study?\",\"answer\":\"The study identifies the HOPS complex and the protein NPC1 as essential host factors for filovirus entry.\"},{\"question\":\"What methodology was used to discover these factors?\",\"answer\":\"The researchers utilized a haploid genetic screen to identify genes that are necessary for filoviral entry into host cells.\"},{\"question\":\"Why are these findings significant for research?\",\"answer\":\"These findings are significant because they clarify the molecular mechanisms of filovirus entry, which provides potential targets for developing new antiviral therapies.\"}]","A Haploid Genetic Screen Identifies the HOPS Complex and NPC1 as Host Factors for Filovirus Entry | PPT"]