[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406514-105":59,"doc-detail-406514-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-genetic-profiling-guideline-to-support-diagnosis-and-clinical-management-of-lymphomas","A genetic profiling guideline to support diagnosis and clinical management of lymphomas","","The new lymphoma classifications embed genetics into diagnosis, enabling improved subclassification, patient risk stratification, and prediction of treatment response. Lymphomas show few recurrent, disease-specific mutations, yet most entities present heterogeneous genetic landscapes with many low-frequency events. Multiple studies link genetic markers to enhanced diagnostics and prognostication, while next-generation sequencing is becoming essential in clinical laboratories. This review guides NGS for lymphomas and proposes targeted panels to detect mutations and copy-number alterations in B- and NK/T-cell lymphomas.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-genetic-profiling-guideline-to-support-diagnosis-and-clinical-management-of-lymphomas/406514/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-genetic-profiling-guideline-to-support-diagnosis-and-clinical-management-of-lymphomas/406514.png","ImageObject",300,407,{"name":92,"@type":93},"SANS","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do the latest lymphoma classifications use genetics in diagnosis?","Question",{"text":112,"@type":113},"They incorporate genetic alterations as integral criteria, supporting better lymphoma subclassification, patient risk stratification, and prediction of treatment response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is next-generation sequencing important in lymphoma diagnostics and management?",{"text":117,"@type":113},"Many diagnostic and prognostic genetic markers exist, and NGS is becoming a key tool in clinical laboratories for capturing these alterations.",{"name":119,"@type":110,"acceptedAnswer":120},"What sequencing panel strategy does the review recommend for lymphomas?",{"text":121,"@type":113},"It discusses targeted sequencing panels as a broadly accessible option, including capture-based designs that can detect SNVs, indels, and copy-number alterations, while noting that structural variant detection needs further improvement.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406514,1790817694,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},962090760505,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Clinical and Translational Oncology (2024) 26:1043–1062  \n[https://doi.org/10.1007/s12094-023-03307-1](https://doi.org/10.1007/s12094-023-03307-1)  \nA genetic profiling guideline to support diagnosis and clinical management of lymphomas  \nMargarita Sánchez‑Beato1,2 · Miriam Méndez1,2,3 · María Guirado2,4 · Lucía Pedrosa1 · Silvia Sequero2,5 · Natalia Yanguas‑Casás1 · Luis de la Cruz‑Merino2,6 · Laura Gálvez2,7 · Marta Llanos2,8 · Juan Fernando García9 · Mariano Provencio1,2,10  \nReceived: 27 June 2023 / Accepted: 9 August 2023 / Published online: 6 September 2023 © The Author(s) 2023  \nAbstract  \nThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas. Multiple studies have identified genetic markers that improve diagnostics and prognostication, and nextgeneration sequencing is becoming an essential tool in the clinical laboratory. This review provides a “next-generation sequencing” guide for lymphomas. It discusses the genetic alterations of the most frequent mature lymphoma entities with diagnostic, prognostic, and predictive potential and proposes targeted sequencing panels to detect mutations and copy-number alterations for B-and NK/T-cell lymphomas.  \nKeywords Lymphoma · Next-generation sequencing · Diagnosis · Prognosis  \n*  \n1  \n2  \n3  \n4  \n5  \n6  \nMargarita Sánchez-Beato[msbeato@idiphim.org](msbeato@idiphim.org)  \nServicio de Oncología Médica, Grupo de Investigaciónen Linfomas, Hospital Universitario Puerta de HierroMajadahonda, IDIPHISA, Madrid, Spain  \nGrupo Oncológico para el Tratamiento y Estudio de los Linfomas-GOTEL, Madrid, Spain  \nServicio de Oncología Médica, Hospital Universitario Puerta de Hierro-Majadahonda, IDIPHISA, Madrid, Spain  \nServicio de Oncología Médica, Hospital General Universitario de Elche, Alicante, Spain  \nServicio de Oncología Médica, Hospital Universitario San Cecilio, Granada, Spain  \nServicio de Oncología Médica, Facultad de Medicina, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Instituto de Biomedicina de Sevilla (IBID)/CSIC, Seville, Spain  \n7 Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Málaga, Spain  \n8 Servicio de Oncología Médica, Hospital Universitario de Canarias, La Laguna, Sta. Cruz de Tenerife, Spain  \n9 Servicio de Anatomía Patológica, Hospital MD Anderson Cancer Center, Madrid, Spain  \n10 Servicio de Oncología Médica, Departamento de Medicina, Facultad de Medicina, Hospital Universitario Puerta de Hierro-Majadahonda, Universidad Autónoma de Madrid, IDIPHISA, Madrid, Spain  \nIntroduction  \nMature lymphoid malignancies (Hodgkin (HL) and nonHodgkin lymphomas (NHL)) are the most common hematological solid neoplasias. Thanks to the implementation of high-throughput molecular analysis, our knowledge of the molecular characteristics of lymphomas has been strengthened. Lymphoma classification is still mainly based on morphology, immunophenotype, and a few genetic characteristics. However, the new classifications of mature lymphoid neoplasms, the International Consensus Classification (ICC) of Mature Lymphoid Neoplasms [1] and the 5th World Health Organization (WHO) Classification of Lymphoid Neoplasms [2], have incorporated newly developed technologies to improve lymphoma classification and genetic alterations are now part of the criteria applied to lymphoma diagnosis.  \nStandardizing these high-throughput techniques to enable their ful","cbCaimt6EgEiDIdA","https://ap.wps.com/l/cbCaimt6EgEiDIdA","pdf",1674250,"English","# Abstract\n# Introduction\n## Sequencing panels and clinical standardization\n## Review aim\n# Mature B-cell lymphomas\n## Chronic lymphocytic leukemia (CLL)","[{\"question\":\"How do the latest lymphoma classifications use genetics in diagnosis?\",\"answer\":\"They incorporate genetic alterations as integral criteria, supporting better lymphoma subclassification, patient risk stratification, and prediction of treatment response.\"},{\"question\":\"Why is next-generation sequencing important in lymphoma diagnostics and management?\",\"answer\":\"Many diagnostic and prognostic genetic markers exist, and NGS is becoming a key tool in clinical laboratories for capturing these alterations.\"},{\"question\":\"What sequencing panel strategy does the review recommend for lymphomas?\",\"answer\":\"It discusses targeted sequencing panels as a broadly accessible option, including capture-based designs that can detect SNVs, indels, and copy-number alterations, while noting that structural variant detection needs further improvement.\"}]","A genetic profiling guideline to support diagnosis and clinical management of lymphomas | PDF",1790566188]