[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376939-105":59,"doc-detail-376939-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","a-decade-of-therapeutic-challenges-in-synchronous-gynecological-cancers-from-the-bucharest-oncological-institute-read-online-free","A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute - read online free","","The study reviews synchronous gynecological neoplasia (SGN) managed at the Bucharest Oncological Institute over ten years (2012–2022). Among 7419 female patients with genital malignancies, 36 cases involved invasive synchronous primary gynecological cancers (0.5%) and 12 involved one primary gynecological and another primary invasive pelvic cancer. Recurrent, metastatic, and metachronous tumors were excluded. Clinical variables including symptoms, pathology, staging, treatment, and outcomes were recorded, highlighting that Romanian system characteristics affect the most frequent tumor associations, stage at diagnosis, treatment complexity, and survival.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-decade-of-therapeutic-challenges-in-synchronous-gynecological-cancers-from-the-bucharest-oncological-institute-read-online-free/376939/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-decade-of-therapeutic-challenges-in-synchronous-gynecological-cancers-from-the-bucharest-oncological-institute-read-online-free/376939.png","ImageObject",300,407,{"name":92,"@type":93},"Connor ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does the study evaluate about synchronous gynecological cancers?","Question",{"text":113,"@type":114},"It presents patient characteristics and outcomes for a decade of synchronous gynecological neoplasia cases treated at the Bucharest Oncological Institute.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many patients were included and what types of synchronous cases were identified?",{"text":118,"@type":114},"Across 2012–2022, 7419 patients with genital malignancies were treated; 36 had invasive synchronous primary gynecological cancers and 12 had one primary gynecological plus another primary invasive pelvic cancer.",{"name":120,"@type":111,"acceptedAnswer":121},"Why can SGNs require extensive surgery in some settings?",{"text":122,"@type":114},"In countries with low HPV vaccination and poor screening adherence, SGNs may present at extremely advanced stages, making radical surgery such as pelvic exenterations necessary.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},376939,1790657221,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41},687207022233,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","diagnostics  \nArticle  \nA Decade of Therapeutic Challenges in Synchronous  \nGynecological Cancers from the Bucharest Oncological Institute  \nLaurentiu Simion 1,2, Elena Chitoran 1,2, *, Ciprian Cirimbei 1,2,*, Daniela-Cristina Stefan 1, Ariana Neicu 3, Bogdan Tanase 4, Sinziana Octavia Ionescu 1,2,*, Dan Cristian Luca 1,2, Laurentia Gales 1,5,  \nAdelina Silvana Gheorghe 1,5, Dana Lucia Stanculeanu 1,5 and Vlad Rotaru 1,2  \nCitation: Simion, L.; Chitoran, E.; Cirimbei, C.; Stefan, D.-C.; Neicu, A.; Tanase, B.; Ionescu, S.O.; Luca, D.C.; Gales, L.; Gheorghe, A.S.; et al. A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute. Diagnostics 2023, 13, 2069 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)diagnostics13122069  \nAcademic Editor: Dah Ching Ding  \nReceived: 23 March 2023  \nRevised: 9 June 2023  \nAccepted: 12 June 2023  \nPublished: 15 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania; [lasimion@yahoo.com](lasimion@yahoo.com) (L.S.); [cristinastefan10@gmail.com](cristinastefan10@gmail.com) (D.-C.S.); [luca_dan94@yahoo.com](luca_dan94@yahoo.com) (D.C.L.); [laurentia.gales@yahoo.com](laurentia.gales@yahoo.com) (L.G.); [adelina-silvana.gheorghe@drd.umfcd.ro](adelina-silvana.gheorghe@drd.umfcd.ro) (A.S.G.); [dana.stanculeanu@umfcd.ro](dana.stanculeanu@umfcd.ro) (D.L.S.); [rotaru.vlad@gmail.com](rotaru.vlad@gmail.com) (V.R.)  \n2 Department of Oncological Surgery I, Bucharest Oncological Institute, 022328 Bucharest, Romania  \n3 Department of Pathology, Bucharest Oncological Institute, 022328 Bucharest, Romania; [ariana.neicu@gmail.com](ariana.neicu@gmail.com)  \n4 Department of Thoracic Surgery, Bucharest Oncological Institute, 022328 Bucharest, Romania; [bogdansen@gmail.com](bogdansen@gmail.com)  \n5 Department of Medical Oncology, Bucharest Oncological Institute, 022328 Bucharest, Romania  \n* Correspondence: [chitoran.elena@gmail.com](chitoran.elena@gmail.com) (E.C.); [cirimbei@yahoo.com](cirimbei@yahoo.com) (C.C.); [sinzianaionescu30@gmail.com](sinzianaionescu30@gmail.com) (S.O.I.); Tel.: +40-725-529-700 (E.C.); +40-722-268-749 (C.C.);+40-723-958-076 (S.O.I.)  \nAbstract: The aim of our study is to present the particularities of a specific subset of gynecological cancer patients in Romania. We present a review of synchronous gynecological neoplasia (SGN) treated in the Bucharest Oncological Institute's surgery departments over a decade. Between 2012 and 2022, 7419 female patients with genital malignancies were treated. We identified 36 patients with invasive synchronous primary gynecological cancers (0.5%) and 12 cases with one primary gynecological and another primary invasive pelvic cancer (rectal/bladder) . All recurrent, metastatic, or metachronous tumors detected were excluded. Demographic data, personal history, presenting symptoms, pathologic findings, staging, treatment, and evolution for each case were recorded. Usually, the most common SGN association is between ovarian and endometrial cancer of endometrioid differentiation (low-grade malignancies with very good prognosis) . However, we noticed that, given the particularities of the Romanian medical system, the most frequent association is between cervical and endometrial, followed by cervical and ovarian cancers. Moreover, the cancer stage at diagnosis is more advanced. In countries with low HPV vaccination rate and low adherence to screening programs, SGNs can present as extremely advanced cases and require extensive surgery (such as pelvic exenterations) to achieve radicality. This mult","cbCaieheKHoWNsUr","https://ap.wps.com/l/cbCaieheKHoWNsUr","pdf",1461848,12,"English","# Introduction\n## Diagnosis of synchronous gynecological malignancies\n## Treatment recommendations in synchronous gynecological malignancies","[{\"question\":\"What does the study evaluate about synchronous gynecological cancers?\",\"answer\":\"It presents patient characteristics and outcomes for a decade of synchronous gynecological neoplasia cases treated at the Bucharest Oncological Institute.\"},{\"question\":\"How many patients were included and what types of synchronous cases were identified?\",\"answer\":\"Across 2012–2022, 7419 patients with genital malignancies were treated; 36 had invasive synchronous primary gynecological cancers and 12 had one primary gynecological plus another primary invasive pelvic cancer.\"},{\"question\":\"Why can SGNs require extensive surgery in some settings?\",\"answer\":\"In countries with low HPV vaccination and poor screening adherence, SGNs may present at extremely advanced stages, making radical surgery such as pelvic exenterations necessary.\"}]","A Decade of Therapeutic Challenges in Synchronous Gynecological Cancers from the Bucharest Oncological Institute - read online free | PDF",1790222192]