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Dysregulation is reported across multiple cancers with clinical associations, and MIR100HG also contributes to dilated cardiomyopathy, intervertebral disk degeneration, and pulmonary fibrosis in human 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review on the role of MIR100HG in human disorders  \nSoudeh Ghafouri-Fard1  | Atefeh Harsij2 | Hossein Farahzadi2 | Bashdar Mahmud Hussen3 | Mohammad Taheri4,5 | Majid Mokhtari6  \n1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2Phytochemistry Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \n3 Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq  \n4Urology and Nephrology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran 5Institute of Human Genetics, Jena University Hospital, Jena, Germany 6Skull Base Research Centre, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran  \nCorrespondence  \nMohammad Taheri, Urology and Nephrology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [Email:](Email: mohammad.taheri@uni-jena.de)[ mohammad.taheri@uni-jena.de](Email: mohammad.taheri@uni-jena.de)  \nMajid Mokhtari, Skull Base Research Centre, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.  \n[Email:](Email: majimokh@gmail.com)[ majimokh@gmail.com](Email: majimokh@gmail.com)  \nAbstract  \nMIR100HG is a long non-coding RNA (lncRNA) encoded by a locus on chr11:122,028,203-122,556,721 . This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF-β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.  \nK E Y WO R D S  \ncancer, cardiomyopathy, fibrosis, lncRNA, MIR100HG  \n1 | INTRODUCTION  \nLong noncoding RNAs (lncRNAs) are transcripts with sizes more than 200 nucleotides that do not encode proteins. These transcripts play critical regulatory role in numerous biological events through various mechanisms, including regulation of chromatin structure, interaction with other RNA molecules, sequestering miRNAs and serving as scaffolds for establishment of protein complexes.1 Genes encoding lncRNAs can be categorized according to their relation with other genes in the genome. MicroRNA-host-gene-derived lncRNAs (MIRHGs) are a group of lncRNAs derived from miRNA host genes  \nas a result of pre-miRNA processing.2 About 17% of miRNAs are estimated to be produced by MIRHGs.3 The processing of MIRHGs is functionally related with synthesis of the encoded miRNAs. Notably, MIRHGs have been shown to play important functions in fundamental cellular events and pathogenesis of diseases.2  \nThe molecular crosstalk between lncRNAs and miRNAs plays a fundamental role in the development of a number of diseases mainly through lncRNA/miRNA sponging mechanisms. The sponging effect of lncRNAs on miRNAs attenuates the repression of mRNAs by miRNAs.4 These effects have been best studied in cancer where lncRNA-miRNA axes regulate apoptosis and autophagy. Moreover,  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.  \nthese axes influence tumour metastases through regulation of epithelial-mesenchymal transition (EMT) and expression of matrix metallopro","cbCaimwsB4TSYrKb","https://ap.wps.com/l/cbCaimwsB4TSYrKb","pdf",1604236,12,"English","# Introduction\n## Long noncoding RNAs and MIRHGs\n## lncRNA–miRNA crosstalk and disease relevance\n## MIR100HG genomic features and transcripts\n## MIR100HG expression, splicing, and cell-cycle effects","[{\"question\":\"What is MIR100HG and where is it located?\",\"answer\":\"MIR100HG is a long non-coding RNA (lncRNA) encoded on chr11:122,028,203-122,556,721.\"},{\"question\":\"How does MIR100HG influence cellular processes?\",\"answer\":\"It regulates cell proliferation, apoptosis, cell-cycle transitions, and differentiation.\"},{\"question\":\"Which signaling pathways and disorders are linked to MIR100HG?\",\"answer\":\"It is functionally related to TGF-β, Wnt, Hippo, and ERK/MAPK signaling pathways, and its dysregulation is associated with cancers and conditions including dilated cardiomyopathy, intervertebral disk degeneration, and pulmonary fibrosis.\"}]","A concise review on the role of MIR100HG in human disorders | PDF",1790234291]