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This review consolidates evidence on miR-877 to clarify its molecular mechanisms and clinical relevance across multiple malignancies. Dysregulated miR-877 levels in diverse cancers correlate with oncogenic or tumor-suppressive functions and influence proliferation, migration, and invasion via cell-cycle pathways, supporting prognostic value for early detection and metastasis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-comprehensive-study-on-signal-transduction-and-therapeutic-role-of-mir-877-in-human-cancers/379030/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-comprehensive-study-on-signal-transduction-and-therapeutic-role-of-mir-877-in-human-cancers/379030.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is miR-877 and why is it studied in cancer?","Question",{"text":112,"@type":113},"miR-877 is a microRNA involved in epigenetic regulation of gene expression. It is studied because its dysregulation is linked to cancer development and treatment-relevant outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does miR-877 contribute to tumor behavior?",{"text":117,"@type":113},"The review links miR-877 to cell proliferation, migration, invasion, and apoptosis. 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Nikpoor4  \n1Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, 2Department of Biology, Faculty of Science, Guilan University, Rasht, Iran, 3Department of Radiology, Besat Hospital, Hamedan University of Medical Sciences, Hamedan, Iran, 4Department of Medical Genetics,  \nFaculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran  \nAbstract  \nMicroRNAs are a group of short non‑coding RNAs (miRNAs), which are epigenetically involved in gene expression and other cellular biological processes and can be considered as potential biomarkers for cancer detection and support for treatment management. This review aims toamass the evidence in order to reach the molecular mechanism and clinical significance of miR‑877 in different types of cancer. Dysregulation of miR‑877 level in various types of malignancies as bladder cancer, cervical cancer, cholangiocarcinoma, colorectal cancer (CRC), gastric cancer, glioblastoma, head and neck squamous cell carcinoma (HNSCC), hepatocellular carcinoma, laryngeal squamous cell carcinoma, melanoma, non‑small cell lung cancer (NSCLC), oral squamous cell carcinoma, ovarian cancer (OC), pancreatic ductal adenocarcinoma, and renal cell carcinoma (RCC) have reported, significantly increase or decrease in its level, which can be indicated to its function as oncogene or tumor suppressor. MiR‑877 is involved in cell proliferation, migration, and invasion through cell cycle pathways in cancer. MiR‑877 could be potential a candidate as a valuable biomarker for prognosis in various cancers. Through this study, we proposed that miR‑877 can potentially be a candidate as a prognostic marker for early detection of tumor development, progression, as well as metastasis.  \nKeywords: Biomarker, cancer, microRNA, microRNA‑877, miR‑877  \nAddress for correspondence: Dr. Amin R. Nikpoor, Department of Medical Immunology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.  \nE‑mail: [nikpoora@hums.ac.ir](nikpoora@hums.ac.ir); [Nikpoora@gmail.com](Nikpoora@gmail.com)  \nSubmitted: 31‑Dec‑2021; Revised: 07‑May‑2022; Accepted: 16‑May‑2022; Published: 15‑May‑2023  \nIntroductIon  \nAbout 20000 protein‑coding genes constitute 2% of human’s gene. It has been proposed that at least 70% of the sequences should be transcribed into RNAs; and most transcripts have been identified as non‑coding RNAs (ncRNAs) .[1‑5] As to the latest advancements in sequencing and genome sequencing at large scale, the long nRNAs (more than 200 nucleotides) and short ncRNAs (less than 20 nucleotides) are the principal regulators of the human genome. [6‑8] MicroRNAs are non‑coding, endogenous, single‑stranded, and small molecules the regulate across a mammalian genome and human genome can encode around 1000 types of them. They are found in eukaryotes and are approximately 22‑24 nucleotides long.[9] The main job done by them is post‑transcription regulations,  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website:\u003Cbr>[www.advbiores.net](www.advbiores.net) |\n|  | DOI:\u003Cbr>10.4103/abr.abr_412_21 |\n\nwhich is done through interaction with mRNA and silencing the target gene. MicroRNA are mostly generated in intron regions of other genes and their transcription is mostly done by RNA polymerase II.[10] It is essential to do deeper studies to detect new biological events pertinent to carcinogenesis and also new treatment targets like microRNAs. The microRNAs had different expression in different cancerous tissues so that the expression can be increased, decreased, or remained stable.[11] In human body, MiR‑877 is constituted of two homologous miRNAs on human chromosome 6p21.33, hsa‑miR‑877‑5p and hsa‑miR‑877‑3p.[12,13] The Rfold web server (Vi","cbCailgO1aHOcHz5","https://ap.wps.com/l/cbCailgO1aHOcHz5","pdf",508404,"English","# Abstract\n# Introduction\n# Changes in miR-877 in Different Tumors","[{\"question\":\"What is miR-877 and why is it studied in cancer?\",\"answer\":\"miR-877 is a microRNA involved in epigenetic regulation of gene expression. It is studied because its dysregulation is linked to cancer development and treatment-relevant outcomes.\"},{\"question\":\"How does miR-877 contribute to tumor behavior?\",\"answer\":\"The review links miR-877 to cell proliferation, migration, invasion, and apoptosis. It also describes involvement through cell-cycle pathways.\"},{\"question\":\"In which cancers is miR-877 dysregulated?\",\"answer\":\"The document reports dysregulation across multiple malignancies, including bladder cancer, cervical cancer, cholangiocarcinoma, colorectal cancer, gastric cancer, glioblastoma, and non-small cell lung cancer, among others.\"}]","A Comprehensive Study on Signal Transduction and Therapeutic Role of miR-877 in Human Cancers | PDF",1790233773,23]