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NRF3 (NFE2L3), a cap 'n' collar transcription factor, plays a complex role in the pathogenesis of various diseases, including cancer tumorigenesis and progression. Its regulatory mechanisms—posttranslational modifications and interactions with other transcription factors—are crucial for understanding its impact on cancer biology. Literature review and bioinformatics synthesize upstream and downstream genes, molecules, pathways, and mechanisms, showing a dual role as tumor suppressor or oncogene depending on cellular context and tumor microenvironment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-comprehensive-review-of-the-emerging-role-of-nrf3-in-ovarian-cancer-tumorigenesis-and-progression/353832/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-comprehensive-review-of-the-emerging-role-of-nrf3-in-ovarian-cancer-tumorigenesis-and-progression/353832.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is NRF3 and why is it relevant to ovarian cancer?","Question",{"text":112,"@type":113},"NRF3 (NFE2L3) is a cap 'n' collar transcription factor. 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Journal of Ovarian Research (2026) 19:94 Journal of Ovarian Research  \n[https://doi.org/10.1186/s13048-026-01987-1](https://doi.org/10.1186/s13048-026-01987-1)  \nREVIEW Open Access  \nA comprehensive review of the emerging  role of NRF3 in ovarian cancer tumorigenesis and progression  \nMahdi Hosseinzadeh 1,2, Abbas Karimi1, Mohsen Rashid 1 and Mohammad Reza Sadegi1*  \nAbstract  \nOvarian cancer (OC) presents a formidable public health challenge, characterized by rising incidence rates and high mortality. NRF3 (NFE2L3), a cap 'n' collar transcription factor, plays a complex role in the pathogenesis of various diseases, including cancer tumorigenesis and progression. Its regulatory mechanisms, including posttranslational modifications and interactions with other transcription factors, are crucial for understanding its impact on cancer biology. A thorough examination of existing literature categorizes upstream and downstream genes, molecules, pathways, and mechanisms associated with NRF3, emphasizing its intricate roles and molecular actions in OC. NRF3 exhibits a dual role as a potential tumor suppressor or oncogene, depending on the cellular context and tumor microenvironment. Evidence from a comprehensive literature search and bioinformatics investigation reveals a pan-cancer link between NRF3 and key processes such as chemoresistance, immune evasion, and metastasis, with elevated expression correlating with poor survival outcomes in OC. Its oncogenic mechanisms within the tumor microenvironment highlight immunosuppressive roles that may compromise therapy responses, underscoring its potential as a theranostic biomarker in OC. Emerging evidence suggests that targeting NRF3 may offer novel therapeutic strategies, potentially enhancing treatment outcomes through combination therapies and immunotherapeutic approaches. Our review emphasizes the necessity for further translational research to validate NRF3 as a therapeutic target and biomarker, aiming to improve patient stratification and treatment efficacy in OC. Ultimately, understanding NRF3's multifaceted roles may pave the way for innovative, personalized treatment strategies that address the unique challenges posed by OC.  \nKeywords Ovarian Cancer (OC), Pan-Cancer, NRF3 (NFE2L3), Theranostic Biomarker, Tumor Microenvironment, Translational Research  \n*Correspondence: Mohammad Reza Sadegi [sadeghimr@tbzmed.ac.ir](sadeghimr@tbzmed.ac.ir)  \n1Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran 2Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/licenses/by-nc-nd/4.0/](vecommons.org/licenses/by-nc-nd/4.0/.)[.](vecommons.org/licenses/by-nc-nd/4.0/.)  \nHosseinzadeh et al. Journal of Ovarian Research (2026) 19:94  \nIntroduction  \nOvarian cancer (OC) is a pressing health issue, characterized by its rising incidence and high mortality rates. Globall","cbCaij56vdVLbl4o","https://ap.wps.com/l/cbCaij56vdVLbl4o","pdf",3383531,17,"English","# Introduction\n## NRF3 as a cap 'n' collar transcription factor\n# NRF3 in ovarian cancer: mechanisms and evidence\n## Upstream and downstream regulatory networks\n## Dual role in tumor suppression and oncogenesis\n# NRF3 as a biomarker and therapeutic target\n## Chemoresistance, immune evasion, and metastasis\n## Translational research and combination strategies","[{\"question\":\"What is NRF3 and why is it relevant to ovarian cancer?\",\"answer\":\"NRF3 (NFE2L3) is a cap 'n' collar transcription factor. The review highlights its regulatory involvement in processes that support ovarian cancer tumorigenesis and progression.\"},{\"question\":\"How does NRF3 influence ovarian cancer outcomes?\",\"answer\":\"Evidence compiled in the review indicates a link between NRF3 and key processes such as chemoresistance, immune evasion, and metastasis. Elevated NRF3 expression correlates with poor survival outcomes in OC.\"},{\"question\":\"Does the review suggest NRF3 can be targeted therapeutically?\",\"answer\":\"Yes. The review proposes that targeting NRF3 may enable novel therapeutic strategies, including combination therapies and immunotherapeutic approaches, while emphasizing the need for further translational validation.\"}]","A comprehensive review of the emerging role of NRF3 in ovarian cancer tumorigenesis and progression | PDF",1790107454,43]