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It also evaluates genetic alterations, methylation status, immune cell infiltration effects, chemotherapy responses, and proposes molecular mechanisms. Results show CEP55 upregulation in tumors versus normal tissues, associated with poorer prognosis, altered tumor-immune microenvironment markers, and differential drug responsiveness, supporting CEP55 as a predictive biomarker and therapeutic 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Therapeutic Target  \nMohamed Samir A. Zaki 1,†, Muhammad Alaa Eldeen 2, *,†, Waleed K. Abdulsahib 3, Ayed A. Shati 4, Youssef A. Alqahtani 4, Saleh M. Al-Qahtani 4, Hassan M. Otifi 5, Ashwag Asiri 4, Hesham M. Hassan 5, Hebatallah Emam Mohammed Ahmed 6, Samy A. Dawood 4, Amr Negm 7,8 and Refaat A. Eid 5  \nCitation: Zaki, M.S.A.; Eldeen, M.A.; Abdulsahib, W.K.; Shati, A.A.; Alqahtani, Y.A.; Al-Qahtani, S.M.; Otifi, H.M.; Asiri, A.; Hassan, H.M.; Emam Mohammed Ahmed, H.; et al. A Comprehensive Pan-Cancer Analysis Identifies CEP55 as a Potential Oncogene and Novel Therapeutic Target. Diagnostics 2023, 13, 1613. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)diagnostics13091613  \nAcademic Editors: Andrea De Giglio and Alessandro Di Federico  \nReceived: 25 February 2023  \nRevised: 27 March 2023  \nAccepted: 8 April 2023  \nPublished: 2 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Anatomy Department, College of Medicine, King Khalid University, Abha P.O. Box 62529, Saudi Arabia  \n2 Cell Biology, Histology & Genetics Division, Biology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt  \n3 Pharmacology and Toxicology Department, College of Pharmacy, Al Farahidi University, Baghdad 00965, Iraq  \n4 Department of Child Health, College of Medicine, King Khalid University, Abha P.O. Box 62529, Saudi Arabia  \n5 Pathology Department, College of Medicine, King Khalid University, Abha P.O. Box 62529, Saudi Arabia  \n6 Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Benha University, Banha 13511, Egypt  \n7 Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia  \n8 Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt  \n* Correspondence: [dr.muhammadalaa@gmail.com](dr.muhammadalaa@gmail.com)  \n† These authors equally contributed to this work.  \nAbstract: Emerging research findings have shown that a centrosomal protein (CEP55) is a potential oncogene in numerous human malignancies. Nevertheless, no pan-cancer analysis has been conducted to investigate the various aspects and behavior of this oncogene in different human cancerous tissues. Numerous databases were investigated to conduct a detailed analysis of CEP55 . Initially, we evaluated the expression of CEP55 in several types of cancers and attempted to find the correlation between that and the stage of the examined malignancies. Then, we conducted a survival analysis to determine the relationship between CEP55 overexpression in malignancies and the patient's survival. Furthermore, we examined the genetic alteration forms and the methylation status of this oncogene. Additionally, the interference of CEP55 expression with immune cell infiltration, the response to various chemotherapeutic agents, and the putative molecular mechanism of CEP55 in tumorigenesis were investigated. The current study found that CEP55 was upregulated in cancerous tissues versus normal controls where this upregulation was correlated with a poor prognosis in multiple forms of human cancers. Additionally, it influenced the level of different immune cell infiltration and several chemokines levels in the tumor microenvironment in addition to the response to several antitumor drugs. Herein, we provide an in-depth understanding of the oncogenic activities of CEP55, identifying it as a possible predictive marker as well as a specific target for developing anticancer therapies.  \nKeywords: CEP55; pan-cancer; methylation; prognosis; tumor immunotherapy; bio","cbCaidbT0AyTFjEu","https://ap.wps.com/l/cbCaidbT0AyTFjEu","pdf",14164347,21,"English","# Introduction\n## Cancer context and need for biomarkers\n# Materials and Methods\n## Databases and analytical approaches\n# Results\n## CEP55 expression across cancers\n## Prognostic value and survival association\n## Genetic alterations and methylation status\n## Immune cell infiltration and chemokines\n## Chemotherapy response correlations\n## Proposed molecular mechanisms\n# Discussion\n## Oncogenic significance and therapeutic implications\n# Conclusion\n## CEP55 as biomarker and target","[{\"question\":\"What is the main objective of this pan-cancer analysis of CEP55?\",\"answer\":\"To evaluate CEP55 expression patterns and characterize how CEP55 behaves across different human cancers, including its clinical relevance and underlying biological associations.\"},{\"question\":\"How is CEP55 connected to prognosis and patient survival?\",\"answer\":\"The analysis includes survival assessment showing that CEP55 overexpression correlates with poor prognosis in multiple cancer types.\"},{\"question\":\"What additional biological aspects of CEP55 are investigated beyond expression?\",\"answer\":\"The study examines genetic alterations, methylation status, effects on immune cell infiltration and chemokines in the tumor microenvironment, and associations with responses to various chemotherapeutic agents.\"}]","A Comprehensive Pan-Cancer Analysis Identifies CEP55 as a Potential Oncogene and Novel Therapeutic Target | PDF",1790221163,53]