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Participants aged at least 18 years were assigned 1:1 to continuous remimazolam infusion or midazolam. Primary outcome was time to full alertness, with secondary outcome postoperative anterograde amnesia. Remimazolam showed faster recovery and reduced immediate and delayed amnesia versus midazolam.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-comparison-of-the-effect-of-remimazolam-and-midazolam-on-recovery-and-preserved-memory-function-for-patients-with-dental-extraction-anxiety/420333/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-comparison-of-the-effect-of-remimazolam-and-midazolam-on-recovery-and-preserved-memory-function-for-patients-with-dental-extraction-anxiety/420333.png","ImageObject",300,407,{"name":92,"@type":93},"nayy☆","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of comparing remimazolam and midazolam in this trial?","Question",{"text":112,"@type":113},"To determine whether continuous intravenous remimazolam leads to better quality postoperative recovery than midazolam in patients with dental anxiety undergoing impacted wisdom tooth extraction.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants assigned in the study?",{"text":117,"@type":113},"Eligible adults with dental anxiety were randomly assigned 1:1 to receive either continuous intravenous remimazolam or midazolam in a parallel, triple-blinded design.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes did the study measure to assess recovery and memory?",{"text":121,"@type":113},"The primary outcome was the time to complete alertness, and the secondary outcome was postoperative anterograde amnesia, including immediate and delayed effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},420333,1790811908,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090893153,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Drug Design, Development and Therapy  \n Open Access Full Text Article  \nCLINIC AL TRIAL REPORT  \nA Comparison of the Effect of Remimazolam and Midazolam on Recovery and Preserved Memory Function for Patients with Dental Extraction Anxiety  \nQuan Jing 1 , *, Weijia Wang 2 , *, Limeng Wu 1 , Lejunzi Wang2 , Boru Yuan 2 , Yan Wang2 , Chengbin Wang 3 , Lin Liu4 , Lei Guan 5 , Riyue Yu 6 , Yuelun Zhang 7 , Daniel I Sessler8 , 9 , Yuguang Huang2 , Kuo Wan 1 , Lijian Pei 2  \n1Department of Stomatology, Peking Union Medical College Hospital, Beijing, People’s Republic of China; 2Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, People’s Republic of China; 3Department of Anesthesiology, Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Department of Stomatology, Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Department of Anesthesiology, Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China; 6Department of Stomatology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 7Medical Research Center, Peking Union Medical College Hospital, Beijing, People’s Republic of China; 8Center for Outcomes Research and Department of Anesthesiology, UTHealth, Houston, TX, USA; 9Outcomes Research Consortium®, Houston, TX, USA  \n*These authors contributed equally to this work  \nCorrespondence: Lijian Pei, Department of Anesthesiology, Peking Union Medical College Hospital, Dongdan District, No. 1, Shuaifuyuan, Beijing, 100730, People’s Republic of China, Tel +86 18612672127, Fax +86 10 69155581, Email [hazelbeijing@vip.163.com](hazelbeijing@vip.163.com); Kuo Wan, Department of Stomatology, Peking Union Medical College Hospital, Dongdan District, No. 1, Shuaifuyuan, Beijing, 100730, People’s Republic of China, Tel +86 15811185513, [Email wankuo@126.com](Email wankuo@126.com)  \nPurpose: Remimazolam is an ultrashort-acting benzodiazepine, which has been indicated to be effective in endoscopic surgery and general anaesthesia. Research on its use in outpatient dental procedures remains limited. This triple-blinded randomized clinical trial was designed to determine whether the quality of postoperative recovery is better with continuous intravenous remimazolam administration compared with midazolam administration for impacted wisdom tooth extraction in patients with dental anxiety. Patients and Methods: This study was a randomized, parallel triple-blinded, superiority trial conducted between 30 April 2022 and 24 June 2024. Participants aged ≥18 years who exhibited dental anxiety and who were eligible for impacted wisdom tooth extraction inan outpatient setting were included in this study. Participants were randomly assigned at a 1:1 ratio to receive either a continuous intravenous infusion of remimazolam or midazolam. The primary outcome was the time to recover full alertness. The secondary outcome was postoperative anterograde amnesia.  \nResults: A total of 150 participants were randomized in this study, with 75 patients assigned to the remimazolam group and 75 patients assigned to the midazolam group. The time to complete alertness was significantly shorter in the remimazolam group than in the midazolam group (3.0 ± 3.6 min vs 4.7 ± 5.2 min, mean difference, −1.9 min; 95% CI, −3.3min to −0.4 min; P = 0.013) . The odds of immediate and delayed anterograde amnesia were much reduced with remimazolam administration compared with midazolam administration (immediate: 0.14, 95% CI, 0.05 to 0.34, delayed: 0.07, 95% CI, 0.03 to 0.15, both P \u003C 0.001) .  \nConclusion: For patients with dental anxiety, remimazolam offers not only faster recovery, but also a much better restoration of memory function compared with midazolam.  \nTrial Registration: [https://clinicaltrials.gov/study/NCT05350085](https://clinicaltrials.gov/study/NCT05350085) .  \nPlain Language Summary:  \nThis study compared the effects of t","cbCaifNhYeGY14qB","https://ap.wps.com/l/cbCaifNhYeGY14qB","pdf",1640555,11,"English","# Purpose\n# Patients and Methods\n## Primary outcome\n## Secondary outcome\n# Results\n# Conclusion\n# Trial Registration\n# Plain Language Summary\n# Keywords\n# Introduction","[{\"question\":\"What was the main goal of comparing remimazolam and midazolam in this trial?\",\"answer\":\"To determine whether continuous intravenous remimazolam leads to better quality postoperative recovery than midazolam in patients with dental anxiety undergoing impacted wisdom tooth extraction.\"},{\"question\":\"How were participants assigned in the study?\",\"answer\":\"Eligible adults with dental anxiety were randomly assigned 1:1 to receive either continuous intravenous remimazolam or midazolam in a parallel, triple-blinded design.\"},{\"question\":\"What outcomes did the study measure to assess recovery and memory?\",\"answer\":\"The primary outcome was the time to complete alertness, and the secondary outcome was postoperative anterograde amnesia, including immediate and delayed effects.\"}]","A Comparison of the Effect of Remimazolam and Midazolam on Recovery and Preserved Memory Function for Patients with Dental Extraction Anxiety | PDF",1790620496,28]