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Gross total resection is achieved in most cases and is strongly associated with seizure freedom at a mean 7.2-year follow-up. Recurrence or progression is linked to anaplastic histology and subtotal resection, while classic low-grade tumors demonstrate excellent long-term survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-clinicoradiological-series-of-39-gangliogliomas-insights-into-surgical-outcomes-and-prognostic-factors/452681/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-clinicoradiological-series-of-39-gangliogliomas-insights-into-surgical-outcomes-and-prognostic-factors/452681.png","ImageObject",300,407,{"name":42,"@type":43},"hdkawk","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study design and how many patients were included?","Question",{"text":63,"@type":64},"The study retrospectively reviewed 39 patients with histologically confirmed gangliogliomas. Clinical, imaging, surgical, and follow-up data were analyzed.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which clinical presentation and tumor locations were most common?",{"text":68,"@type":64},"Epilepsy was the most common presenting symptom (94.9%). Tumors were predominantly temporal, followed by cerebellar and parietal locations.",{"name":70,"@type":61,"acceptedAnswer":71},"How did gross total resection relate to seizure outcomes and prognosis?",{"text":72,"@type":64},"Gross total resection was achieved in 71.8% of cases and was significantly associated with seizure freedom (Engel Class I). Overall prognosis for classic low-grade tumors was excellent, with 100% 10-year survival for low-grade tumors.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},452681,1790797578,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":118,"preview_page_count":4},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","CLINICAL RESEARCH  \nA Clinicoradiological Series of 39 Gangliogliomas: Insights into Surgical Outcomes and Prognostic Factors  \nMoustafa A. Mansour, MBBCh, MSc, MPhil 1, Amr K. Elsamman, MD, PhD, FACS2  \n1Department of Neurosurgery, Nasser Institute for Research and Treatment, Cairo, Egypt; 2Department of Neurosurgery, Faculty of Medicine, Cairo University, Giza, Egypt  \nCorrespondence: Moustafa A. Mansour, MBBCh, MSc, MPhil, Department of Neurosurgery, Nasser Institute for Research and Treatment, 1351 Nile Corniche, As Sahel, El Sahel,  \nCairo Governorate 4350210, [Egypt. Email:](Egypt. Email: Moustafa.Medavatar@gmail.com)[ Moustafa.Medavatar@gmail.com](Egypt. Email: Moustafa.Medavatar@gmail.com)  \nReceived, September 05, 2025; Accepted, October 30, 2025; Published Online, January 8, 2026.  \nNeurosurgery Practice 2026;7(1):e000194. [https://doi.org/10.1227/neuprac.0000000000000194](https://doi.org/10.1227/neuprac.0000000000000194)  \n© The Author(s) 2026. Published by Wolters Kluwer Health, Inc. on behalf of Congress of Neurological Surgeons. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nBACKGROUND AND OBJECTIVES: Gangliogliomas (GGs) are rare, well-differentiated glioneuronal tumors, representing a common cause of neoplastic epilepsy. This study analyzes the presentation, management, and outcomes of a large single-center cohort.  \nMETHODS: We retrospectively reviewed 39 patients with histologically confirmed GG. Data on demographics, clinical presentation, imaging, surgical management, and follow-up were analyzed.  \nRESULTS: The mean patient age was 20.8 years. The most common presenting symptom was epilepsy (94.9%, 37/39), with complex partial seizures being predominant. Tumors were predominantly temporal (46.2%, 18/39), followed by cerebellar (15.4%, 6/39) and parietal (12.8%, 5/39) locations. A solid-cystic morphology was the most common radiological pattern (51.3%, 20/39). Gross total resection (GTR) was achieved in 71.8%(28/39) of cases. At a mean follow-up of 7.2 years, 86.5%(32/37) of patients with preoperative epilepsy were seizure-free (Engel Class I) . Seizure freedom was significantly associated with GTR (P \u003C .001) . Recurrence/progression was observed in 7 patients (17.9%), strongly associated with anaplastic histology (P \u003C .001), and subtotal resection (P = .003) . The overall prognosis was excellent for classic GG, with a 100% 10-year survival rate for low-grade tumors.  \nCONCLUSION: GGs have a favorable prognosis after GTR, with excellent rates of seizure control. Tumor recurrence, though rare, is linked to high-grade features and incomplete resection. This series underscores the importance of maximal safe resection as the primary treatment.  \nKEY WORDS: Ganglioglioma, Epilepsy surgery, Seizure outcome, Gross total resection, Anaplastic, Brain tumor  \nG  \nangliogliomas (GGs) are rare, slow-growing neuroepithelial tumors that account for approximately 0.5% - 5% of all primary central nervous system tumors and  \nrepresent a leading cause of neoplastic epilepsy in children and young adults.1,2 Histopathologically, these tumors are distinguished by their mixed composition of dysplastic neuronal elements and neoplastic glial components, predominantly astrocytic, which imparts both epileptogenic potential and proclivity for indolent growth.2,3 The temporal lobe is the most commonly affected site, and epilepsy, often drug-resistant, dominates the clinical presentation.3  \nWhile prior studies have broadly characterized GGs as World Health Organization (WHO) grade I or II tumors with generally  \nfavorable outcomes, rarer anaplastic GGs (AGGs, WHO grade III) are recognized as high grade, malignant tumors posing significant challenges becaus","cbCaihCUgYuT1HtI","https://ap.wps.com/l/cbCaihCUgYuT1HtI","pdf",1007394,"English","# Background and Objectives\n# Methods\n# Results\n# Conclusion\n# Key Words","[{\"question\":\"What was the study design and how many patients were included?\",\"answer\":\"The study retrospectively reviewed 39 patients with histologically confirmed gangliogliomas. Clinical, imaging, surgical, and follow-up data were analyzed.\"},{\"question\":\"Which clinical presentation and tumor locations were most common?\",\"answer\":\"Epilepsy was the most common presenting symptom (94.9%). Tumors were predominantly temporal, followed by cerebellar and parietal locations.\"},{\"question\":\"How did gross total resection relate to seizure outcomes and prognosis?\",\"answer\":\"Gross total resection was achieved in 71.8% of cases and was significantly associated with seizure freedom (Engel Class I). Overall prognosis for classic low-grade tumors was excellent, with 100% 10-year survival for low-grade tumors.\"}]","A Clinicoradiological Series of 39 Gangliogliomas - Insights into Surgical Outcomes and Prognostic Factors | PDF",1790737563]