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Women born in 1947 or earlier were invited for a GP-collected cell sample; screening and follow-up samples were analyzed centrally with region-specific follow-up procedures. CIN2 served as the recommended treatment threshold. Outcomes included CIN2+ and CIN3+ detection rates, and counts of biopsies and conizations, plus annual incident cervical cancer numbers for 2009–2020.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-cervical-screening-initiative-for-elderly-women-in-denmark/378878/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-cervical-screening-initiative-for-elderly-women-in-denmark/378878.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What population and screening approach were evaluated in the study?","Question",{"text":113,"@type":114},"The study evaluated a one-time HPV screening in 2017 for Danish women aged 70 and older, using a cell sample collected by their general practitioner after personal invitation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were follow-up and treatment thresholds defined?",{"text":118,"@type":114},"Follow-up was carried out using region-specific procedures, and CIN2 was used as the recommended treatment threshold, with follow-up involving colposcopy, biopsy, and cervical sampling.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key findings on CIN2+ detection and follow-up practices?",{"text":122,"@type":114},"Among screened women, five per 1000 had CIN2+ (95% CI: 5–6). Detection of CIN2+ was highest in regions where conization was used as part of first-line follow-up.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378878,1790303815,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","DOI: 10. 1111/aogs.14574  \nOR I G I NAL R E S E AR C H ART I C L E  \nA cervical screening initiative for elderly women in Denmark  \nMalene Skorstengaard1 | Petra Hall Viborg2 | Ane Birgitte Telén Andersen2 | Berit Andersen3,4 | Mary Holten Bennetsen5 | Kirsten Marie Jochumsen6 | Tonje Johansen5 | Lise Grupe Larsen7 | Maja Ulrikka Bruun Laustsen2 | Rouzbeh Salmani7 | Reza Serizawa8 | Marianne Waldstrøm4 | Elsebeth Lynge1   \n1Nykøbing Falster Hospital, Nykøbing Falster, Denmark  \n2Danish Clinical Registries (RKKP), Frederiksberg/Aarhus N, Denmark 3 Department of Public Health Programs, University Research Clinic for Cancer Screening, Randers Regional Hospital, Randers, Denmark  \n4Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark 5Department of Pathology, Randers Regional Hospital, Randers, Denmark 6Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark  \n7Department of Pathology, Zealand Regional Hospital, Næstved/Roskilde, Denmark  \n8 Department of Pathology, Hvidovre Hospital, Hvidovre, Denmark  \nCorrespondence  \nElsebeth Lynge, Nykøbing Falster Hospital, Ejegodvej 63, DK 4800 Nykøbing Falster, Denmark.  \nEmail: [elsebeth@sund.ku.dk](elsebeth@sund.ku.dk)  \nFunding information  \nKræftens Bekæmpelse, Grant/Award Number: R247-A14608  \nAbstract  \nIntroduction: To assess outcome of a one-time human papillomavirus (HPV)-screening in 2017 of Danish women aged 70+.  \nMaterial and methods: Women born 1947 or before were personally invited to have a cell-sample collected by their general practitioner. Screening-and follow-up samples were analyzed in hospital laboratories in the five Danish regions and registered centrally. Follow-up procedures varied slightly across regions. Cervical intraepithelial neoplasia 2 (CIN2) was recommended treatment threshold. Data were retrieved from the Danish Quality Database for Cervical Cancer Screening. We calculated CIN2+ and CIN3+ detection rates per 1000 screened women, and number of biopsies and conizations per detected CIN2+ case. We tabulated annual number of incident cervical cancer cases in Denmark for the years 2009–2020.  \nResults: In total, 359 763 women were invited of whom 108 585 (30% of invited) were screened; 4479 (4 . 1% of screened, and 4. 3% of screened 70–74 years) tested HPVpositive; of whom 2419 (54% of HPV-positive) were recommended follow-up with colposcopy, biopsy and cervical sampling, and 2060 with cell-sample follow-up. In total, 2888 women had histology; of whom 1237 cone specimen and 1651 biopsy only. Out of 1000 screened women 11 (95% confidence interval [CI]: 11–12) had conization. In total, 579 women had CIN2+; 209 CIN2, 314 CIN3, and 56 cancer. Out of 1000 screened women five (95% CI: 5–6) had CIN2+. Detection rate of CIN2+ was highest in regions where conization was used as part of first-line follow-up. In 2009– 2016, number of incident cervical cancers in women aged 70+ in Denmark fluctuated around 64; in 2017 it reached 83 cases; and by 2021 the number had decreased to 50. Conclusions: The prevalence of high-risk HPV of 4. 3% in women aged 70–74 is in agreement with data from Australia, and the detection of five CIN+2 cases per 1000 screened women is in agreement with data for 65–69 year old women in Norway. Data are thus starting to accumulate on primary HPV-screening of elderly women.  \n\n| Abbreviations: CBC, colposcopy, biopsy and cervical sampling; CI, confidence interval; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; RR, relative risk. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.\u003Cbr>© 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics ","cbCaidFQ96rKOi8G","https://ap.wps.com/l/cbCaidFQ96rKOi8G","pdf",2212155,"English","# Abstract\n## Introduction\n## Material and methods\n## Results\n## Conclusions\n# Keywords\n# Introduction (context)","[{\"question\":\"What population and screening approach were evaluated in the study?\",\"answer\":\"The study evaluated a one-time HPV screening in 2017 for Danish women aged 70 and older, using a cell sample collected by their general practitioner after personal invitation.\"},{\"question\":\"How were follow-up and treatment thresholds defined?\",\"answer\":\"Follow-up was carried out using region-specific procedures, and CIN2 was used as the recommended treatment threshold, with follow-up involving colposcopy, biopsy, and cervical sampling.\"},{\"question\":\"What were the key findings on CIN2+ detection and follow-up practices?\",\"answer\":\"Among screened women, five per 1000 had CIN2+ (95% CI: 5–6). Detection of CIN2+ was highest in regions where conization was used as part of first-line follow-up.\"}]","A cervical screening initiative for elderly women in Denmark | PDF",1790233000,25]