[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-434265-105":59,"doc-detail-434265-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","a-case-report-of-a-rare-subacute-cutaneous-lupus-erythematosus-with-chin-prostration","A Case Report of a Rare Subacute Cutaneous Lupus Erythematosus with Chin Prostration","","Subacute cutaneous lupus erythematosus (SCLE) is a clinical subtype of cutaneous lupus erythematosus, an autoimmune connective tissue disease marked by photosensitive rashes. This report documents a rare SCLE case involving the chin that had been repeatedly misdiagnosed. Integrated assessment of dermoscopic features, reflectance confocal microscopy (RCM) findings, and skin biopsy enabled definitive diagnosis. Systemic corticosteroids and immunomodulators produced marked lesion regression at 19 weeks, supporting dermoscopy plus RCM for accurate, real-time monitoring.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-case-report-of-a-rare-subacute-cutaneous-lupus-erythematosus-with-chin-prostration/434265/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-case-report-of-a-rare-subacute-cutaneous-lupus-erythematosus-with-chin-prostration/434265.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What condition is described in this case report?","Question",{"text":113,"@type":114},"The case report describes a rare presentation of subacute cutaneous lupus erythematosus (SCLE) involving the chin.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the correct diagnosis established?",{"text":118,"@type":114},"Diagnosis was established by integrated evaluation of dermoscopic features, reflectance confocal microscopy (RCM) findings, and histopathological examination with skin biopsy.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatment was used and what was the outcome?",{"text":122,"@type":114},"The patient received combination therapy with systemic corticosteroids and immunomodulators, with significant lesion regression observed at the 19-week follow-up.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},434265,1791006579,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Clinical, Cosmetic and Investigational Dermatology  \n Open Access Full Text Article  \nC ASE REPORT  \nA Case Report of a Rare Subacute Cutaneous Lupus Erythematosus with Chin Prostration  \nWanni Li 1 , 2 , *, Wen Luo 1 , *, Yujia Liang 1 , 2 , Ping Wang 1 , 2 , Chunxia Wang 1 , 2 , Jiejie Lu 1 , 2 , Weiwei Wu 1 , 2  \n1Department of Dermatology, Affiliated Dermatology Hospital of Hainan Medical University, Haikou, People’s Republic of China; 2Department of Dermatology, The Fifth People’s Hospital of Hainan Province, Haikou, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Weiwei Wu; Jiejie Lu, Department of Dermatology, The Fifth People’s Hospital of Hainan Province, No. 8 Longhua Road, Longhua District, Haikou, Hainan, People’s Republic of China, Tel +86 13647541729; +86 13519816255, Email [vigorwu@126.com](vigorwu@126.com); [lujiejie677@163.com](lujiejie677@163.com)  \n\n| Abstract: Subacute cutaneous lupus erythematosus (SCLE) is a clinical subtype of cutaneous lupus erythematosus (CLE), an autoimmune connective tissue disease characterized by photosensitive rashes. This report presents a rare case of SCLE involving the chin. The patient presented with an annular, erythematous, scaling plaque on the left chin, which had been repeatedly misdiagnosed. Through integrated analysis of dermoscopic features, reflectance confocal microscopy (RCM) findings, and skin biopsy, a definitive diagnosis was established. Combination therapy with systemic corticosteroids and immunomodulators was initiated. Significant lesion regression was observed at the 19-week follow-up. The combined application of dermoscopy and RCM optimizes clinical management by reducing diagnostic errors and enabling real-time treatment monitoring.\u003Cbr>Keywords: subacute cutaneous lupus erythematosus, dermoscopy, reflective confocal microscopy, pathological biopsy |\n| --- |\n| Introduction\u003Cbr>Subacute cutaneous lupus erythematosus (SCLE) is a clinical subtype of cutaneous lupus erythematosus (CLE) . It is an autoimmune connective tissue disease that is characterized by photosensitive rashes. Ultraviolet radiation, viral infections, tobacco use, environmental pollution, and trauma can trigger SCLE by inducing keratinocytes to express associated antigens. This process activates multiple signaling pathways, promotes autoantigen transfer, and initiates other inflammatory responses.1,2 There are currently no universally established diagnostic criteria for SCLE. Its diagnosis is primarily based on a combination of clinical presentation, histopathological examination, and serological findings. SCLE typically presents as polycyclic annular and/or psoriasiform papulosquamous lesions. However, due to its morphological similarity to conditions such as granuloma annulare, erythema annulare centrifugum, psoriasis, and tinea corporis, it is frequently misdiagnosed.3 In addition, SCLE is closely related to systemic lupus erythematosus (SLE) . As the disease progresses, SCLE can involve multiple systems and organs, gradually transforming into SLE. Therefore, SCLE is regarded as one of the diagnostic criteria for SLE.4\u003Cbr>Skin microscopy and RCM are simple, rapid, and non-invasive auxiliary diagnostic tools that have become an important part of the skin disease diagnostic process. They are quite helpful for the early diagnosis and differential diagnosis of skin diseases, in addition to the evaluation of changes in condition and severity.5,6 They play a crucial role in the guidance of CLE diagnosis and treatment.\u003Cbr>This article reports a case of SCLE in the chin area that was repeatedly misdiagnosed over an extended period. Through a systematic analysis of its clinical presentation, dermoscopic and RCM features, histopathological findings, and treatment outcomes, we aim to improve the recognition of atypical SCLE manifestations, enhance diagnostic accuracy, and refine the clinical diagnostic approach for this condition. |\n\nReceived: 2 September","cbCaikvEprbgzUuJ","https://ap.wps.com/l/cbCaikvEprbgzUuJ","pdf",590469,"English","# Introduction\n# Case Presentation\n## Clinical features\n## Diagnostic workup\n# Discussion\n# Conclusion","[{\"question\":\"What condition is described in this case report?\",\"answer\":\"The case report describes a rare presentation of subacute cutaneous lupus erythematosus (SCLE) involving the chin.\"},{\"question\":\"How was the correct diagnosis established?\",\"answer\":\"Diagnosis was established by integrated evaluation of dermoscopic features, reflectance confocal microscopy (RCM) findings, and histopathological examination with skin biopsy.\"},{\"question\":\"What treatment was used and what was the outcome?\",\"answer\":\"The patient received combination therapy with systemic corticosteroids and immunomodulators, with significant lesion regression observed at the 19-week follow-up.\"}]","A Case Report of a Rare Subacute Cutaneous Lupus Erythematosus with Chin Prostration | PDF",1790668237,13]