[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458492-105":59,"doc-detail-458492-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-case-of-thiazide-induced-pancreatitis","A Case of Thiazide-Induced Pancreatitis","","Acute pancreatitis is pancreatic inflammation most often triggered by gallstones or alcohol, with other rarer etiologies including autoimmune causes, metabolic abnormalities, envenomation, trauma, idiopathic disease, post-ERCP injury, or medication effects. This case describes a 72-year-old woman on hydrochlorothiazide who presented with severe epigastric pain radiating to the back, stable hemodynamics, and elevated lipase. Imaging confirmed acute interstitial pancreatitis without necrosis or alternative sources, and follow-up excluded malignancy, supporting thiazide-induced disease by exclusion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-case-of-thiazide-induced-pancreatitis/458492/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-case-of-thiazide-induced-pancreatitis/458492.png","ImageObject",300,407,{"name":92,"@type":93},"Đào","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What causes acute pancreatitis in adults, and what other causes were considered here?","Question",{"text":112,"@type":113},"Gallstones and alcohol are the most common causes. Other causes considered include autoimmune disease, hypercalcemia, hypertriglyceridemia, scorpion sting, trauma, idiopathic disease, post-ERCP, and drug-induced etiologies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What findings supported the diagnosis of thiazide-induced pancreatitis?",{"text":117,"@type":113},"Work-up showed markedly elevated lipase with leukocytosis, while tests and imaging were negative for other causes such as cholelithiasis, trauma, scorpion sting, steroid use, autoimmune markers, hypercalcemia, hypertriglyceridemia, and recent ERCP. Subsequent outpatient follow-up showed no malignancy, and exclusion supported the thiazide diuretic as the likely cause.",{"name":119,"@type":110,"acceptedAnswer":120},"How is drug-induced pancreatitis managed according to the article’s discussion?",{"text":121,"@type":113},"Management includes supportive care and withdrawal of the offending agent. Early identification requires a high index of suspicion, since ongoing exposure can predispose patients to recurrent pancreatitis and fatal complications.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458492,1790796190,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Review began 11/18/2025  \nReview ended 11/30/2025  \nPublished 12/08/2025  \n© Copyright 2025  \nAlmajed et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98739  \nOpen Access Case Report  \nA Case of Thiazide-Induced Pancreatitis  \nAbdulla Almajed 1, Shooq Alsebaie 2, Nora McVinnie 1, Augusto R. Fernandez-Aristi 1, Jasmine Omar 1, Megan Dekker 1  \n1. Internal Medicine, Henry Ford Health System, Detroit, USA 2. Cardiology, Mohammed Bin Khalifa Bin Salman Al Khalifa Specialist Cardiac Centre, Awali, BHR  \nCorresponding author: Abdulla Almajed, [abdulla.ramzi.almajed@gmail.com](abdulla.ramzi.almajed@gmail.com)  \nAbstract  \nAcute pancreatitis is the inflammation of the pancreas that is most commonly caused by gallstones or alcohol in adults. Other less likely causes are autoimmune, hypercalcemia, hypertriglyceridemia, scorpion sting, trauma, idiopathic, post-endoscopic retrograde cholangiopancreatography (ERCP), or drug-induced. Our patient is a 72-year-old woman with a past medical history of hypertension (on hydrochlorothiazide 12.5 mg, amlodipine 10 mg, and losartan 100 mg), chronic hypoxic respiratory failure, and previous deep vein thrombosis (DVT) (on apixaban 2.5 mg) who presented to the emergency department with complaints of abdominal pain. She was hemodynamically stable with epigastric pain that radiated to the back and was tender on palpation. Work-up revealed a lipase of 9, 130 IU/L, normal lipid profile, leukocytosis of 13,500 cells/mm3, and negative urinalysis. Imaging computed tomography (CT) of the abdomen shows acute interstitial pancreatitis with no glandular necrosis, no regional venous thrombosis, and no signs ofcholelithiasis. Work-up was negative for other causes of acute pancreatitis: no recent history of trauma, no recent scorpion sting, no steroid use, low autoimmune pancreatitis antibodies, normal calcium levels, normal triglycerides, and no recent history of ERCP. CT of the abdomen as an outpatient follow-up after eight weeks revealed no underlying malignancy. On the basis of exclusion, the patient 's thiazide diuretic was likely the cause of her acute pancreatitis with no other possible causes.  \nIn clinical presentations with no typical identifiable causes, it is important to have a high index of suspicion of other rare causes. In this case, an accurate medication reconciliation and a high index of suspicion allowed for the identification of this possible but less common cause.  \nCategories: Pharmacology, Internal Medicine, Gastroenterology  \nKeywords: adverse effect, drug-induced acute pancreatitis, gastroenterology, pancreatitis, thiazide  \nIntroduction  \nAcute pancreatitis (AP) is an inflammatory process of the pancreas with a wide spectrum of clinical presentations ranging from mild presentations to severe that require in-hospital admission. In the United States, the incidence of AP is four per 1000 people with approximately 130,000 new cases annually and a mortality rate of 3 .5%[1] . The most common causes ofAP are gallstones and alcohol in the United States. Other less common causes are hypertriglyceridemia, autoimmune diseases, trauma, endoscopic retrograde cholangiopancreatography (ERCP), and medications. Drug-induced pancreatitis is rare and accounts for less than 2% of cases in the United States [2] .  \nThere are currently over 500 medications in the literature that have been reported to cause drug-induced pancreatitis [3] . Diagnosis of drug-induced pancreatitis requires the diagnosis of AP initially. If the work-up for other causes of AP is negative and the patient is on a medication that can cause pancreatitis, then the diagnosis of drug-induced pancreatitis can be made [4] . This diagnosis is on the basis of temporal association, but causality is often difficult to ","cbCaiiXcqo8ZVQDq","https://ap.wps.com/l/cbCaiiXcqo8ZVQDq","pdf",2316543,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What causes acute pancreatitis in adults, and what other causes were considered here?\",\"answer\":\"Gallstones and alcohol are the most common causes. Other causes considered include autoimmune disease, hypercalcemia, hypertriglyceridemia, scorpion sting, trauma, idiopathic disease, post-ERCP, and drug-induced etiologies.\"},{\"question\":\"What findings supported the diagnosis of thiazide-induced pancreatitis?\",\"answer\":\"Work-up showed markedly elevated lipase with leukocytosis, while tests and imaging were negative for other causes such as cholelithiasis, trauma, scorpion sting, steroid use, autoimmune markers, hypercalcemia, hypertriglyceridemia, and recent ERCP. Subsequent outpatient follow-up showed no malignancy, and exclusion supported the thiazide diuretic as the likely cause.\"},{\"question\":\"How is drug-induced pancreatitis managed according to the article’s discussion?\",\"answer\":\"Management includes supportive care and withdrawal of the offending agent. Early identification requires a high index of suspicion, since ongoing exposure can predispose patients to recurrent pancreatitis and fatal complications.\"}]","A Case of Thiazide-Induced Pancreatitis | PDF",1790753409,18]