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The report describes a 73-year-old woman with a left maxillary gingival mass in whom cytology indicated squamous cell carcinoma. 18FDG-PET/CT demonstrated increased uptake in the left maxillary gingiva, cervical lymph nodes, and the main pancreatic duct. Endoscopic evaluation with EGD biopsy confirmed invasive intraductal papillary mucinous carcinoma (IPMC). She was diagnosed with synchronous double primary cancers and declined radical treatment, dying 11 months later.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-case-of-synchronous-double-cancers-consisting-of-maxillary-gingival-carcinoma-and-intraductal-papillary-mucinous-carcinoma-invasive-case-report/377170/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-case-of-synchronous-double-cancers-consisting-of-maxillary-gingival-carcinoma-and-intraductal-papillary-mucinous-carcinoma-invasive-case-report/377170.png","ImageObject",300,407,{"name":42,"@type":43},"Nguyễn Văn Học","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What cancers were diagnosed in this synchronous double cancer case?","Question",{"text":63,"@type":64},"The patient had maxillary gingival carcinoma and an invasive intraductal papillary mucinous carcinoma (IPMC) in the pancreas, diagnosed as synchronous primary malignancies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the tumors detected and confirmed?",{"text":68,"@type":64},"Cytology identified squamous cell carcinoma in the gingiva, while 18FDG-PET/CT showed uptake in the gingiva, cervical nodes, and pancreatic duct. 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BMCOral Health (2023) 23:595 [https://doi.org/10.1186/s12903-023-03253-y](https://doi.org/10.1186/s12903-023-03253-y)  \nBMC Oral Health  \n CASE REPORT Open Access  \nA case of synchronous double cancers  \nconsisting of maxillary gingival carcinoma and intraductal papillary mucinous carcinoma, invasive: case report  \nRyosuke Iwama1* , Hitoshi Miyashita 1, Atsumu Koketsu 1, Kiyoshi Kume2, Fumiyoshi Fujishima3, Atsushi Masamune2 and Tetsu Takahashi1  \nAbstract  \nBackground The development of synchronous multiple primary cancers is one of the major causes of death in patients with head and neck cancer. Herein, we report a case of synchronous intraductal papillary mucinous carcinoma (IPMC), invasive in a patient with maxillary gingival carcinoma.  \nCase presentation A 73-year-old female visited our hospital complaining of a mass on the left side of the maxillary gingiva. Intraorally, an exophytic tumor, 50 × 25 mm in size, was found on the gingiva of the left maxillary posterior, and a diagnosis of squamous cell carcinoma was revealed by cytology. Emission tomography/ computed tomography with 18 Fluorodeoxyglucose-Positron (18FDG-PET/ CT) showed increased accumulation in the left maxillary gingiva, the left side of cervical lymph nodes, and the main pancreatic duct. The pancreatic ductal tumor was performed the biopsy at esophagogastroduodenoscopy (EGD) and resulted in a pathological diagnosis of IPMC, invasive. The patient was diagnosed as synchronous double primary cancers consisting of maxillary gingival carcinoma cT4aN2bM0 and IPMC, invasive cT3N0M0 . She refused radical treatment, and died 11 months later.  \nConclusion 18FDG-PET/ CT, EGD and multidisciplinary approach is required for the detection and determining the treatment strategy of synchronous double primary cancers.  \nKeywords Synchronous double cancers, Maxillary gingival carcinoma, Intraductal papillary mucinous neoplasm  \nBackground  \nHead and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer in the world [1], with a high rate of development of multiple primary carcinomas [2].  \n*Correspondence:  \nRyosuke Iwama [Ryosuke.iwama.d2@tohoku.ac.jp](Ryosuke.iwama.d2@tohoku.ac.jp)  \n1 Division of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, Japan  \n2 Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan  \n3 Department of Pathology, Tohoku University Hospital, Sendai, Japan  \nMultiple primary cancers were defined by Warren et al. as the following: 1) each tumor shows a certain malignant image, 2) each tumor is located in mutually distant sites, and 3) one is not a metastasis of the other [3]. Moertelet al. defined multiple primary cancers as being synchronous if they are detected within 6 months of the primary cancer [4]. The presence of synchronous multiple primary cancers is a major clinical problem and a leading cause of death in patients with head and neck cancer [5].  \nIt has been reported that synchronous multiple primary cancers are highly prevalent in the head and neck region, upper gastrointestinal tract, and lungs  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.or","cbCaircq5qCATNBx","https://ap.wps.com/l/cbCaircq5qCATNBx","pdf",1634679,"English","# Abstract\n# Background\n# Case presentation\n# Conclusion\n# Keywords","[{\"question\":\"What cancers were diagnosed in this synchronous double cancer case?\",\"answer\":\"The patient had maxillary gingival carcinoma and an invasive intraductal papillary mucinous carcinoma (IPMC) in the pancreas, diagnosed as synchronous primary malignancies.\"},{\"question\":\"How were the tumors detected and confirmed?\",\"answer\":\"Cytology identified squamous cell carcinoma in the gingiva, while 18FDG-PET/CT showed uptake in the gingiva, cervical nodes, and pancreatic duct. A biopsy via EGD at the pancreatic duct led to the pathological diagnosis of invasive IPMC.\"},{\"question\":\"What was the treatment decision and outcome?\",\"answer\":\"The patient refused radical treatment and died 11 months after the diagnosis.\"}]","A case of synchronous double cancers - consisting of maxillary gingival carcinoma and intraductal papillary mucinous carcinoma, invasive: case report | PDF",1790223527,15]