[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337798-105":59,"doc-detail-337798-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-case-of-squamous-cell-carcinoma-arising-in-disseminated-superficial-porokeratosis","A Case of Squamous Cell Carcinoma Arising in Disseminated Superficial Porokeratosis","","Porokeratosis (PK) is a rare, genetically chronic, progressive skin disorder marked by keratotic lesions with an atrophic center and a prominent peripheral ridge, with cornoid lamella as a hallmark. PK may convert into squamous cell carcinoma (SCC), though transformation from disseminated superficial porokeratosis (DSP) alone is seldom reported. This report describes a patient whose SCC developed from DSP alone and presented with coin-sized lesions progressing to ulceration at the waist. Radiation controlled the SCC while PK persisted, underscoring the value of regular follow-up and comprehensive diagnosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-case-of-squamous-cell-carcinoma-arising-in-disseminated-superficial-porokeratosis/337798/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-case-of-squamous-cell-carcinoma-arising-in-disseminated-superficial-porokeratosis/337798.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is disseminated superficial porokeratosis (DSP) and why is it clinically important?","Question",{"text":112,"@type":113},"DSP is a form of porokeratosis characterized by cornoid-lamella histology. It is clinically important because porokeratosis can transform into non-melanoma skin cancers, including squamous cell carcinoma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the patient’s squamous cell carcinoma develop in this case?",{"text":117,"@type":113},"The patient had a long history of DSP, and the condition gradually progressed from annular brown macules to swelling and plaque formation at the waist. The lesion then ulcerated and was accompanied by mild pain, indicating SCC arising from DSP.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was used and what were the outcomes?",{"text":121,"@type":113},"The patient underwent radiation therapy, which effectively treated the SCC. However, radiation did not resolve the underlying porokeratosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},337798,1790096354,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Clinical, Cosmetic and Investigational Dermatology Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article C ASE REPORT  \nA Case of Squamous Cell Carcinoma Arising in Disseminated Superficial Porokeratosis  \nHui-E Zheng , Yun Wang , Shuhui Wu, Ming-Fang Zhu  \nDepartment of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, People’s Republic of China  \nCorrespondence: Ming-Fang Zhu, Department of Dermatology, The Second Affiliated Hospital of Hunan University of Chinese Medicine, 233 Cai E North Road, Kaifu District, Changsha, People’s Republic of China, Tel +86-13907317358, Fax +86-731-84917727, Email [1220824642@qq.com](1220824642@qq.com)  \n\n| Abstract: Porokeratosis (PK), characterized by keratotic lesions with an atrophic center and a prominent peripheral ridge, with a typical histological hallmark, namely, the cornoid lamella, has two forms: disseminated and localized. While PK often converts into squamous cell carcinoma (SCC), conversion from disseminated superficial porokeratosis (DSP) alone is rarely reported except for one case in which DSP and LP coexisted and converted to SCC. Here, we report the case of a patient with SCC converted from DSP alone, presenting with coin-sized macules on the bottom right of his waist that developed into an ulcer at the center. The patient underwent radiation therapy, which effectively treated the SCC but did not resolve the PK. This article highlights regular follow-up and undergo comprehensive diagnosis, both of which are beneficial to enable early detection and management of DSP that has converted to into SCC; in addition, standardized medical treatment may help improve the treatment therapeutic effect of in similar diseases. Keywords: disseminated superficial porokeratosis, porokeratosis, squamous cell carcinoma |\n| --- |\n| Introduction\u003Cbr>Porokeratosis (PK) is a rare, genetically chronic progressive skin disease characterized by dike-like verrucous bulges at the edges, atrophy in the center, and histological manifestations involving cornoid lamella.1 PK can be classified as porokeratosis of Mibelli (PM), disseminated superficial actinic porokeratosis (DSAP), disseminated superficial porokeratosis (DSP), porokeratosis palmaris et plantaris disseminate (PPPD) and Linear Porokeratosis (LP), etc.2 Porokeratosis often develops into cancer: studies show that 6 .9% to 30% of cases will develop into non-melanoma skin cancer (NMSC),3 including basal cell carcinoma, Merkel cell carcinoma and squamous cell carcinoma, with SCC having the highest risk ratio among the three types.4 According to reports, among the many clinical subtypes of PK, the top three canceration rates of SCC are for LP at 19%, PM at 7 .6%, and DSAP at 3 .4% .4 Compared with other subtypes of PK, there is currently only one reported case of the transformation of DSP into SCC, and it is due to coexistence with LP;5,6 in contrast, in DSP alone, canceration is rare, which may be related to DSP’s relatively rare incidence.7\u003Cbr>In the present report, we describe the case of a 61-year-old male patient with a history of DSP of approximately 20 years and a relevant family medical history who was finally diagnosed with squamous cell carcinoma (SCC) under the premise of no coexistence of multiple PK variants and no history of prolonged sun exposure.\u003Cbr>Case Report\u003Cbr>A 61-year-old male presented with a 20-year history of multiple annular brown macule lesions surrounded by elevated borders all over the body. Twenty years ago, he had undergone total surgical resection at a local hospital, but the diagnosis was not available to us. Although the patient’s condition had improved following total surgical resection, the symptoms suddenly recurred and worsened, despite the absence of sun exposure, 10 years previously. During this period, he did not seek professional medical treatment until one year prior to presentation at our clinic, and was diagnosed with DSP a","cbCaisTHQj4bib4p","https://ap.wps.com/l/cbCaisTHQj4bib4p","pdf",768271,"English","# Introduction\n## Case Report","[{\"question\":\"What is disseminated superficial porokeratosis (DSP) and why is it clinically important?\",\"answer\":\"DSP is a form of porokeratosis characterized by cornoid-lamella histology. It is clinically important because porokeratosis can transform into non-melanoma skin cancers, including squamous cell carcinoma.\"},{\"question\":\"How did the patient’s squamous cell carcinoma develop in this case?\",\"answer\":\"The patient had a long history of DSP, and the condition gradually progressed from annular brown macules to swelling and plaque formation at the waist. The lesion then ulcerated and was accompanied by mild pain, indicating SCC arising from DSP.\"},{\"question\":\"What treatment was used and what were the outcomes?\",\"answer\":\"The patient underwent radiation therapy, which effectively treated the SCC. However, radiation did not resolve the underlying porokeratosis.\"}]","A Case of Squamous Cell Carcinoma Arising in Disseminated Superficial Porokeratosis | PDF",1790020671,13]