[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-328984-en":59,"doc-seo-328984-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":72,"language_code":73,"site_id":74,"html_lang":73,"table_of_contents":75,"faqs":76,"seo_title":77,"seo_description":66,"update_tm":78,"read_time":79},328984,1374391975076,"Riley","https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","A case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis - Case report and review","Multiple primary malignant neoplasms associated with tuberculosis are rare, and the clinical interplay between tuberculosis and tumors remains insufficiently clarified. This case report analyzes the characteristics of three primary tumors coexisting with tuberculosis and summarizes personalized treatment. The patient’s long-term survival after tailored therapy is documented, alongside a maintained good quality of life throughout follow-up, with diagnostic, therapeutic, and outcome details.","®  \n Clinical Case Report   \nA case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis  \nCase report and review  \nYing Chen, MDa ,* , Shu Luo, MDa , Quan Zheng, BSb , Qing Yu, BSc , Chunxia Liu, BSa , Rui Tang, MDa , Fei Chen, BSa , Yan Zhang, PhDd  \n\n| Abstract\u003Cbr>Rationale: Multiple primary malignant neoplasms with tuberculosis are rare. The interaction between tuberculosis and tumor remains unclear. Moreover, the treatment of multiple primary tumors combined with tuberculosis is relatively complicated. Herein, we report a case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis.\u003Cbr>Objective: This report aims to analyze the clinical characteristics of 3 primary tumors combined with tuberculosis. We report the long-term survival of this patient after personalized treatment and this patient have a good quality of life.\u003Cbr>Diagnoses and interventions: A 55-year-old male patient was diagnosed with squamous cell carcinoma of the lower thoracic esophagus (cT4bN1M0 IVA) and received concurrent chemoradiotherapy, followed by 2 cycles consolidate chemotherapy. During the follow-up, he was diagnosed with secondary tuberculosis (TB) and accepted anti-TB treatment. During anti-TB treatment, he was diagnosed with squamous cell carcinoma of the oropharynx (cT1N0M0 I P16(‐)), then he received radical radiation therapy. However, within a year, the patient was diagnosed with oral squamous cell carcinoma (cT3N0M0 IIIA) . He accepted an individualized chemotherapy with paclitaxel combined with capecitabine. Moreover, immunohistochemistry of the patient’s 3 biopsies indicated positive P53 expression.\u003Cbr>Outcomes: Since the patient suffered from esophageal cancer, oropharyngeal cancer, and oral floor cancer, no tumor recurrence or metastasis was observed. And he has a good quality of life. Tuberculosis, TP53 mutation, radiotherapy, smoking, and drinking history may be risk factors for multiple primary tumors.\u003Cbr>Lessons: The treatment of multiple primary tumors combined with pulmonary tuberculosis is complicated. Individualized treatment allows patients to achieve long-term survival while also having a good quality of life. Limitations in this case: surgery may be an alternative strategy for the patient, but the patient refused surgery.\u003Cbr>Abbreviations: MPMNs = multiple primary malignant neoplasms, SPCs = second primary tumors, TB = tuberculosis. |\n| --- |\n| Keywords: metachronous triple primary carcinoma, multiple primary neoplasms, P53 , squamous cell carcinoma, tuberculosis |\n\n1. Introduction  \nWith the progress of medical diagnosis and treatment, the survival of cancer patients is prolonged, and the incidence of multiple primary malignant neoplasms (MPMNs) is increasing.[1] In epidemiological studies, the incidence of multiple primaries is reported to be in the range of 2% to 17% .[2] In a Chinese retrospective study, MPMNs accounted for 1.12% of all malignancies (270/24,105) .[3] Triple cancer is reported to be in the range of only 0.03% to 0.16%.[4,5] Moreover, MPMNs combined with  \npulmonary tuberculosis is rare. Therefore, we report a case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis. From 2017 to 2022, the patient developed esophageal squamous cell carcinoma, tuberculosis, oropharyngeal cancer, and oral floor cancer. The patient is still alive after radiotherapy, chemotherapy, and antituberculosis therapy. At present, the pathogenesis and risk factors of multiple primary malignant tumors are still unclear. We report the long-term survival of this patient after treatment and review the relevant literature.  \nThis research was supported by the Sichuan Medical Association of Sichuan Province of China (No. S20091).  \nInformed consent was secured from the patient.  \nThe authors have no conflicts of interest to disclose.  \nData sharing not applicable to this article as no datasets were generated or analyzed during the current study.  \nThe study wa","cbCaim2u1dCSnd4m","https://ap.wps.com/l/cbCaim2u1dCSnd4m","pdf",723632,"English","en",105,"# Abstract\n# Introduction\n# Case presentation\n## Diagnoses and interventions\n## Outcomes\n# Lessons\n# Abbreviations","[{\"question\":\"Why are multiple primary malignant neoplasms with tuberculosis clinically important in this report?\",\"answer\":\"The report states that multiple primary malignant neoplasms with tuberculosis are rare and that the interaction between tuberculosis and tumor remains unclear, making management more complex.\"},{\"question\":\"What treatments were given for the three primary cancers combined with tuberculosis?\",\"answer\":\"The patient received concurrent chemoradiotherapy for lower thoracic esophageal squamous cell carcinoma, then consolidation chemotherapy. After secondary tuberculosis was diagnosed and treated, he received radical radiation for oropharyngeal squamous cell carcinoma. For later oral squamous cell carcinoma, he received individualized chemotherapy with paclitaxel plus capecitabine.\"},{\"question\":\"What were the key outcomes and proposed risk factors mentioned?\",\"answer\":\"No tumor recurrence or metastasis was observed, and the patient had a good quality of life. The report suggests tuberculosis, TP53 mutation, radiotherapy, smoking, and drinking history as possible risk factors for multiple primary tumors.\"}]","A case of metachronous triple primary carcinoma complicated with pulmonary tuberculosis - Case report and review | PDF",1789981947,13,{"code":4,"msg":81,"data":82},"ok",{"site_id":74,"language":73,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":139,"head_meta":141,"extra_data":143,"updated_unix":144},"a-case-of-metachronous-triple-primary-carcinoma-complicated-with-pulmonary-tuberculosis-case-report-and-review","",{"@graph":86,"@context":138},[87,101,121],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,99],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":35,"@type":93,"position":98},"https://docshare.wps.com/document/healthcare/",3,{"item":100,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/a-case-of-metachronous-triple-primary-carcinoma-complicated-with-pulmonary-tuberculosis-case-report-and-review/328984/",{"url":100,"name":65,"@type":102,"image":103,"author":108,"headline":65,"publisher":110,"fileFormat":113,"inLanguage":73,"description":66,"dateModified":114,"datePublished":115,"encodingFormat":113,"isAccessibleForFree":116,"interactionStatistic":117},"DigitalDocument",{"url":104,"@type":105,"width":106,"height":107},"https://docshare.wps.com/thumbnails/a-case-of-metachronous-triple-primary-carcinoma-complicated-with-pulmonary-tuberculosis-case-report-and-review/328984.png","ImageObject",300,407,{"name":63,"@type":109},"Person",{"url":91,"name":111,"@type":112},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":118,"interactionType":119,"userInteractionCount":34},"InteractionCounter",{"@type":120},"ViewAction",{"@type":122,"mainEntity":123},"FAQPage",[124,130,134],{"name":125,"@type":126,"acceptedAnswer":127},"Why are multiple primary malignant neoplasms with tuberculosis clinically important in this report?","Question",{"text":128,"@type":129},"The report states that multiple primary malignant neoplasms with tuberculosis are rare and that the interaction between tuberculosis and tumor remains unclear, making management more complex.","Answer",{"name":131,"@type":126,"acceptedAnswer":132},"What treatments were given for the three primary cancers combined with tuberculosis?",{"text":133,"@type":129},"The patient received concurrent chemoradiotherapy for lower thoracic esophageal squamous cell carcinoma, then consolidation chemotherapy. After secondary tuberculosis was diagnosed and treated, he received radical radiation for oropharyngeal squamous cell carcinoma. For later oral squamous cell carcinoma, he received individualized chemotherapy with paclitaxel plus capecitabine.",{"name":135,"@type":126,"acceptedAnswer":136},"What were the key outcomes and proposed risk factors mentioned?",{"text":137,"@type":129},"No tumor recurrence or metastasis was observed, and the patient had a good quality of life. The report suggests tuberculosis, TP53 mutation, radiotherapy, smoking, and drinking history as possible risk factors for multiple primary tumors.","https://schema.org",{"og:url":100,"og:type":140,"og:title":65,"og:site_name":111,"og:description":66},"article",{"robots":142,"canonical":100},"index,follow",{"doc_id":61,"site_id":74},1790120540]