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Gastrointestinal stromal tumors (GISTs) can occur in the small intestine and show overlapping imaging findings, creating diagnostic difficulty. A 17-year-old woman presented with melena, abdominal pain, and anemia; CT suggested a GIST, but laparoscopic resection and histopathology confirmed MD with fundic gland-type ectopia.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-case-of-meckels-diverticulum-misdiagnosed-as-gastrointestinal-stromal-tumor-case-report-and-literature-review/415297/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-case-of-meckels-diverticulum-misdiagnosed-as-gastrointestinal-stromal-tumor-case-report-and-literature-review/415297.png","ImageObject",300,407,{"name":92,"@type":93},"Sophia Brooks","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What makes Meckel’s diverticulum difficult to diagnose preoperatively?","Question",{"text":113,"@type":114},"MD may mimic other small-intestinal lesions because it can overlap with imaging features of tumors such as GIST, and preoperative diagnostic rates in symptomatic patients are reported as less than 10%.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why did imaging strongly suggest a gastrointestinal stromal tumor in this case?",{"text":118,"@type":114},"Small-bowel CT showed a nodular lesion attached to the intestinal wall with marked homogeneous enhancement, a pattern that strongly suggested a GIST.",{"name":120,"@type":111,"acceptedAnswer":121},"How was the diagnosis ultimately confirmed?",{"text":122,"@type":114},"The patient underwent laparoscopic segmental resection, and postoperative pathology confirmed Meckel’s diverticulum with fundic gland-type ectopia.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},415297,1790696064,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962084925636,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","TYPE Case Report  \nPUBLISHED 19 December 2025 DOI 10.3389/fmed.2025.1672019  \nOPEN ACCESS  \nEDITED BY  \nFabio Grizzi,  \nHumanitas Research Hospital, Italy  \nREVIEWED BY  \nVipul Yagnik,  \nBanas Medical College and Research Institute, India  \nRamiro Vargas Aignasse,  \nUniversidad Católica de Córdoba, Argentina  \n*CORRESPONDENCE  \nWei Wei  \n [weiw@jlu.edu.cn](weiw@jlu.edu.cn)  \nRECEIVED 25 November 2025  \nREVISED 22 November 2025  \nACCEPTED 25 November 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nWang B, Li S, Huang G, Tang Z, Ye Z, Wang Mand Wei W (2025) A case of Meckel’s diverticulum misdiagnosed as gastrointestinal stromal tumor: case report and literature review.  \nFront. Med. 12:1672019 .  \ndoi: 10.3389/fmed.2025.1672019  \nCOPYRIGHT  \n© 2025 Wang, Li, Huang, Tang, Ye, Wang and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nA case of Meckel’s diverticulum misdiagnosed as gastrointestinal stromal tumor: case report and literature review  \nBinbin Wang1 , Shuxin Li1 , Gengchen Huang1 , Zhijun Tang1 , Zihao Ye1 , Miao Wang2 and Wei Wei1*  \n1 Department of Urology II, The First Hospital of Jilin University, Changchun, China, 2 Department of Gastrointestinal and Colorectal Surgery, The First Hospital of Jilin University, Changchun, China  \nMeckel’s diverticulum (MD) is a common congenital gastrointestinal malformation often containing ectopic gastric mucosa. It is prone to ulceration and painless lower gastrointestinal bleeding, predominantly affecting children and adolescents. Gastrointestinal stromal tumors (GISTs), which arise from Cajal interstitial cells, are predominantly mesenchymal tumors that occur predominantly in middle-aged and elderly individuals. Both conditions may occur in the small intestine, presenting gastrointestinal bleeding and exhibiting overlapping imaging features, which pose challenges for clinical differentiation. This report describes a 17-years-old female patient admitted to the First Hospital of Jilin University with intermittent melena, abdominal pain, and anemia. Small bowel CT imaging (CTE) revealed a nodular lesion measuring approximately 0 .9 cm 􀀂 1. 8 cm within the ileal lumen. The lesion exhibited abroad base attached to the intestinal wall and showed marked homogeneous enhancement, strongly suggesting a GIST. Previous gastrointestinal endoscopy had only indicated chronic gastritis and colitis. The patient underwent laparoscopic segmental resection of the ileal mass. Postoperative pathology confirmed an MD with fundic gland-type ectopia. This case highlights the diagnostic challenges of complex MD and underscores the critical role of histopathology. It thereby provides diagnostic and surgical guidance for MD cases that mimic GIST on imaging, thereby reducing misdiagnosis.  \nKEYWORDS  \nMeckel’s diverticulum, ectopic gastric mucosa, gastrointestinal stromal tumor, laparoscopic surgery, case report  \n1 Introduction  \nMeckel’s diverticulum (MD) is a common congenital gastrointestinal malformation resulting from incomplete regression of the embryonic vitelline duct ( 1) . Its clinical features are often summarized by the “Rule of 2s”: an incidence of approximately 2%, commonly located on the para mesenteric margin within the proximal 2 feet (approximately 61 cm) of the ileocecal valve, measuring about 2 inches (approximately 5 cm) in length, with a male predominance (approximately 2:1), and symptoms typically presenting before age  \nFrontiers in Medicine 01 [frontiersin.org](frontiersin.org)  \n2 ( 1, 2) . As a true diverticulum, MD comprises the entire wall thickness of the small intestine, with ","cbCailtYuHfr5KYb","https://ap.wps.com/l/cbCailtYuHfr5KYb","pdf",1703990,"English","# Introduction\n# Case Presentation and Diagnostic Workup\n# Treatment and Pathology Findings\n# Discussion and Literature Review\n# Conclusion","[{\"question\":\"What makes Meckel’s diverticulum difficult to diagnose preoperatively?\",\"answer\":\"MD may mimic other small-intestinal lesions because it can overlap with imaging features of tumors such as GIST, and preoperative diagnostic rates in symptomatic patients are reported as less than 10%.\"},{\"question\":\"Why did imaging strongly suggest a gastrointestinal stromal tumor in this case?\",\"answer\":\"Small-bowel CT showed a nodular lesion attached to the intestinal wall with marked homogeneous enhancement, a pattern that strongly suggested a GIST.\"},{\"question\":\"How was the diagnosis ultimately confirmed?\",\"answer\":\"The patient underwent laparoscopic segmental resection, and postoperative pathology confirmed Meckel’s diverticulum with fundic gland-type ectopia.\"}]","A case of Meckel’s diverticulum misdiagnosed as gastrointestinal stromal tumor - case report and literature review | PDF",1790600877,15]