[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-349540-105":59,"doc-detail-349540-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-bibliometric-and-visual-analysis-of-prmts-research-publications-for-cancer-2006-2024","A bibliometric and visual analysis of PRMTs research publications for cancer (2006-2024)","","Protein arginine methyltransferases (PRMTs) are investigated as promising anticancer drug targets, yet the oncology field lacked a dedicated bibliometric synthesis of PRMTs-related publications. This study builds a knowledge map for PRMTs and cancer by summarizing publication status and collaboration patterns, then identifying research hotspots and forward-looking development prospects. Web of Science Core Collection records from 2006-01-01 to 2024-09-07 were analyzed using CiteSpace and reference management with NoteExpress.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-bibliometric-and-visual-analysis-of-prmts-research-publications-for-cancer-2006-2024/349540/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-bibliometric-and-visual-analysis-of-prmts-research-publications-for-cancer-2006-2024/349540.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this bibliometric analysis of PRMTs in cancer research?","Question",{"text":112,"@type":113},"To map the knowledge landscape of PRMTs and cancer by summarizing research status, collaboration patterns, research hotspots, and future development prospects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases and time range were used to collect publications?",{"text":117,"@type":113},"Relevant publications were searched in the Web of Science Core Collection (WOSCC) from January 1, 2006 to September 7, 2024.",{"name":119,"@type":110,"acceptedAnswer":120},"What tools were used for bibliometric and reference management analyses?",{"text":121,"@type":113},"CiteSpace was used for bibliometric visual analyses (countries, institutions, authors, cited journals, keywords, references), and NoteExpress was used to import and manage references.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},349540,1790207997,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","®  \n Bibliometric Review   \nA bibliometric and visual analysis of PRMTs research publications for cancer (2006–2024)  \nMengjia Li, PhDa ,b , Lijing Zhan, MBBSa , Jinlin Cui, MBBSa , Xinle Liu, MBBSa , Liping Wang, MBBSa , Yangyang Han, PhDa ,b ,c ,*  \n\n| Abstract\u003Cbr>Background: Protein arginine methyltransferases (PRMTs) have attracted considerable attention as potential targets for anticancer drug development. However, no bibliometric analysis of research articles on PRMTs in the field of oncology has been reported to date. To establish a knowledge map of PRMTs and cancer, summarize the current status and collaborative patterns of related publications, and explore research hotspots and future development prospects.\u003Cbr>Methods: Using defined topic terms and their corresponding free-text terms, we searched the Web of Science Core Collection (WOSCC) database for relevant publications from January 1, 2006 to September 7, 2024. CiteSpace was used to perform bibliometric analyses of countries, institutions, authors, cited journals, keywords, and references. NoteExpress was used to import, manage, and add references.\u003Cbr>Results: A total of 250 articles related to PRMTs and cancer were retrieved from WOSCC. Visual analysis showed a steady increase in the number of publications from 2006 to 2024. The United States had the highest centrality, whereas China had the highest publication count. The Chinese Academy of Sciences was the most productive institution. Mark T. Bedford was the most prominent and productive author. Cancer Cell had the highest centrality in this field. Based on keyword citation frequency, the leading research topics in current PRMTs and cancer studies were breast cancer, gene expression, coactivator-associatedarginine methyltransferase 1 (CARM1), androgen receptor, and coactivator.\u003Cbr>Conclusion: Overall, PRMTs and cancer research represents a promising research direction, and members of the PRMT family have potential utility as cancer biomarkers and therapeutic targets.\u003Cbr>Abbreviations: aDMA = asymmetric dimethylarginine, CARM1 = coactivator-associated arginine methyltransferase 1, ERα = estrogen receptor alpha, IGF-1R = insulin-like growth factor 1 receptor, LLR = log-likelihood ratio, MMA = monomethylarginine, PRMT = protein arginine methyltransferase, SAM = S-adenosylmethionine, sDMA = symmetric dimethylarginine, WOSCC = Web of Science Core Collection. |\n| --- |\n| Keywords: bibliometric, cancer, CiteSpace, co-occurrence analysis, protein arginine methyltransferases (PRMTs) |\n\n1. Introduction  \nCancer is a leading cause of death and premature mortality worldwide, accounting for nearly 1 in 6 deaths and 30.3% of premature deaths from noncommunicable diseases among individuals aged 30 to 69 years. The cancer burden and cancer ranking vary across countries and development levels, reflecting differences in risk factor exposure, screening, and access to treatment. In 2022, there were approximately 20 million new cancer cases and 9.7 million cancer deaths globally. Based on  \ndemographic projections, the annual number of new cases is expected to reach 35 million by 2050.[1] In China, an estimated 4.82 million new cancer cases and 2.57 million cancer deaths occurred in 2022, with lung cancer being the leading cause of cancer-related death. [2]  \nProtein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is a post-translational modification in which PRMTs transfer a methyl group from S-adenosylmethionine (SAM) to arginine residues in substrate proteins. [3] This modification plays important roles in multiple  \nThis work was supported by the National Natural Science Foundation of China (Grant No. 82260493 and No. 32300465) and Open Research Fund Project of Key Laboratory of High Incidence Disease Research in Xinjiang, Ministry of Education (2025B02).  \nThe authors have no conflicts of interest to declare.  \nThe datasets generated during and/or analyzed during the current study are available f","cbCaibevo9pidYbi","https://ap.wps.com/l/cbCaibevo9pidYbi","pdf",4578813,"English","# Introduction\n## Cancer burden and global trends\n## PRMTs biology and rationale for study\n# Bibliometric Review\n## Data source and search strategy\n## Analytical tools and workflow\n## Results and key findings\n### Publication trends and international/institutional contributions\n### Authors, journals, and keyword hotspots\n### Citation centrality and research topics\n# Conclusion\n# Abbreviations","[{\"question\":\"What is the main purpose of this bibliometric analysis of PRMTs in cancer research?\",\"answer\":\"To map the knowledge landscape of PRMTs and cancer by summarizing research status, collaboration patterns, research hotspots, and future development prospects.\"},{\"question\":\"Which databases and time range were used to collect publications?\",\"answer\":\"Relevant publications were searched in the Web of Science Core Collection (WOSCC) from January 1, 2006 to September 7, 2024.\"},{\"question\":\"What tools were used for bibliometric and reference management analyses?\",\"answer\":\"CiteSpace was used for bibliometric visual analyses (countries, institutions, authors, cited journals, keywords, references), and NoteExpress was used to import and manage references.\"}]","A bibliometric and visual analysis of PRMTs research publications for cancer (2006-2024) | PDF",1790084252,25]