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The diagnosis relies on histologic morphology together with immunohistochemistry. This report describes a 76-year-old man whose epithelioid hemangioendothelioma presented as a groin nodule alongside progressive hemoptysis. Excisional biopsy confirmed the diagnosis; the patient chose palliation and died one month after admission. The case underscores an atypical presentation where hemoptysis and a solitary groin nodule delay recognition, affecting timely management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-76-year-old-man-with-hemoptysis-and-a-groin-nodule-a-case-report/459707/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-76-year-old-man-with-hemoptysis-and-a-groin-nodule-a-case-report/459707.png","ImageObject",300,407,{"name":92,"@type":93},"วิน","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is epithelioid hemangioendothelioma (EHE) and how is it diagnosed in this case?","Question",{"text":112,"@type":113},"EHE is a rare vascular neoplasm with variable behavior. Diagnosis in this case was based on histologic findings from excisional biopsy and immunohistochemistry, including endothelial marker expression such as CD31 and CD34.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What symptoms and findings led to hospitalization?",{"text":117,"@type":113},"The patient presented with progressive hemoptysis and later had increasing oxygen requirements. Imaging showed bilateral multifocal pulmonary nodules with ground-glass halo, and biopsy eventually confirmed EHE.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the groin nodule evaluated and what was the outcome?",{"text":121,"@type":113},"A right pubic nodule developed over months, enlarged to about 3 cm, and was ulcerated. Excisional biopsy confirmed an ulcerated epithelioid vascular tumor consistent with EHE; the patient declined oncologic interventions, chose palliation, and died one month after admission.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},459707,1790756629,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":39,"preview_page_count":4},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","A 76-year-old man with hemoptysis and a groin nodule: A case report  \nKiera Dolan 1, Robert Hayes2 and Mojgan Ebrahimi3  \nSAGE Open Medical Case Reports JCMS Case Reports Volume 14: 1–3 © The Author(s) 2026 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/2050313X251408865](DOI: 10.1177/2050313X251408865)[ ](DOI: 10.1177/2050313X251408865)[journals.sagepub.com/home/sco](journals.sagepub.com/home/sco)  \nAbstract  \nEpithelioid hemangioendothelioma is a rare vascular neoplasm with clinical behavior that varies from indolent to aggressive. While the clinical presentation of epithelioid hemangioendothelioma may be variable, the diagnosis of epithelioid hemangioendothelioma is based on histologic and immunohistochemistry features. We describe a case of epithelioid hemangioendothelioma presenting as a groin nodule in a 76-year-old man. He was admitted to hospital with progressive hemoptysis, accompanied by a growing, ulcerated right groin nodule. Excisional biopsy confirmed a diagnosis of epithelioid hemangioendothelioma. The patient opted for palliation and died 1 month after hospital admission. Our case highlightsan atypical presentation of epithelioid hemangioendothelioma characterized by hemoptysis and a solitary groin nodule, underscoring the importance of timely diagnosis and management.  \nKeywords  \nepithelioid hemangioendothelioma (EHE), vascular neoplasm, immunohistochemistry, hemoptysis, pulmonary nodules  \nReceived: 15 June 2025; accepted: 19 August 2025  \nIntroduction  \nEpithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm with clinical behavior that varies from indolent to aggressive. The clinical presentation and anatomical sites of EHE can be variable; however, EHE most commonly affects soft tissue, lung, and liver.1 The estimated prevalence is fewer than one in a million individuals, primarily affecting adults and with a slight female predominance. 1,2 The characteristic histological features of EHE include epithelioid cells arranged in cords and nests within a myxohyaline stroma.1–5 Tumor cells often contain eosinophilic cytoplasm, round nuclei, and cytoplasmic vacuoles, some of which may contain erythrocytes.1 Diagnosis of EHE requires immunohistochemical analysis, with tumor cells expressing endothelial markers such as CD34, CD31, podoplanin (D2–40), FLI1, and ERG. 1–3,5 Prognosis depends on the anatomical site of involvement and extent of disease at presentation, with~21% of cases developing metastases.1 Treatment for EHE primarily involves surgical excision, with options for metastatic disease that include chemotherapy, immunotherapy, and targeted therapies.4 Given the variation in clinical manifestations of EHE and its potential for multisystem involvement, recognizing atypical presentations is crucial for timely diagnosis and management.  \nCase report  \nA 76-year-old man presented to the emergency department with 9 days of hemoptysis without fever or other systemic symptoms. He had undergone spinal surgery 3 months earlier, complicated by aspiration pneumonia. Prior to admission, bronchoalveolar lavage culture grew Stenotrophomonasmaltophilia, sensitive to multiple antibiotics. Computed tomography (CT) showed bilateral multifocal, ill-defined pulmonary nodules with ground-glass halo. The patient deteriorated despite treatment with trimethoprim/sulfamethoxazole, then levofloxacin and imipenem. Over 2 weeks of admission, hemoptysis worsened with increasing oxygen requirements. CT-guided fine needle biopsy showed normal lung parenchyma with hemosiderin-laden macrophages.  \nAn asymptomatic nodule had appeared over his right pubis 5 months earlier (Figure 1) and grown in size to a 3 cm  \n1 Department of Medicine, Dalhousie University, Saint John, NB, Canada 2Division of Clinical Dermatology and Cutaneous Science, Dalhousie University, Saint John, NB, Canada  \n3Department of Pathology, Dalhousie University, ","cbCaikCnK0CL5By7","https://ap.wps.com/l/cbCaikCnK0CL5By7","pdf",659403,"English","# Abstract\n# Introduction\n# Case report\n# Discussion","[{\"question\":\"What is epithelioid hemangioendothelioma (EHE) and how is it diagnosed in this case?\",\"answer\":\"EHE is a rare vascular neoplasm with variable behavior. Diagnosis in this case was based on histologic findings from excisional biopsy and immunohistochemistry, including endothelial marker expression such as CD31 and CD34.\"},{\"question\":\"What symptoms and findings led to hospitalization?\",\"answer\":\"The patient presented with progressive hemoptysis and later had increasing oxygen requirements. Imaging showed bilateral multifocal pulmonary nodules with ground-glass halo, and biopsy eventually confirmed EHE.\"},{\"question\":\"How was the groin nodule evaluated and what was the outcome?\",\"answer\":\"A right pubic nodule developed over months, enlarged to about 3 cm, and was ulcerated. Excisional biopsy confirmed an ulcerated epithelioid vascular tumor consistent with EHE; the patient declined oncologic interventions, chose palliation, and died one month after admission.\"}]","A 76-year-old man with hemoptysis and a groin nodule - A case report | PDF"]