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Using retrospective data from 2015–2020, the study compares imaging characteristics and cancer detection between men receiving and not receiving 5-ARIs, including biopsy-naïve, previously negative biopsy, and active surveillance cohorts. Results show similar PIRADS distributions and lesion profiles, but fewer cancers detected in the 5-ARI group, suggesting potential confounding of MRI interpretation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/5-alpha-reductase-inhibitors-and-mri-prostates-actively-reducing-prostate-sizes-and-ambiguity/382284/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/5-alpha-reductase-inhibitors-and-mri-prostates-actively-reducing-prostate-sizes-and-ambiguity/382284.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study investigate about 5-ARIs and MRI?","Question",{"text":112,"@type":113},"It examines how 5-ARI therapy affects mpMRI findings and the diagnostic yield of prostate biopsy compared with patients not receiving 5-ARIs.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants selected for the comparison?",{"text":117,"@type":113},"Retrospective consecutive patients undergoing prostate biopsy from 2015 to 2020 were included, including biopsy-naïve men, men with prior negative biopsies, and men on active surveillance for low-grade prostate cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main imaging and biopsy findings?",{"text":121,"@type":113},"On mpMRI, PIRADS distribution, lesion number, and lesion location were not significantly different between groups, while significantly fewer cancers were detected in the 5-ARI group; the lower positive biopsy rate persisted across PIRADS categories.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382284,1790319115,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Wang et al. BMC Urology (2023) 23:61 [https://doi.org/10.1186/s12894-023-01235-4](https://doi.org/10.1186/s12894-023-01235-4)  \nBMC Urology  \n RESEARCH ARTICLE Open Access  \n5-alpha reductase inhibitors and MRI prostates: actively reducing prostate sizesand ambiguity  \nZiting Wang1, Kaiying Wang1* , HanYang Ong2 , Woon Chau Tsang1, Qing Hui Wu1 and Edmund Chiong1,3  \nAbstract  \nBackground Magnetic resonance imaging (MRI) scans are increasingly first-line investigations for suspected prostate cancer, and essential in the decision for biopsy. 5-alpha reductase inhibitor (5-ARI) use has been shown to reduce prostate size and prostate cancer risk. However, insufficient data exists on how 5-ARI use affects MRI findings and yield of biopsy. This study explores the differences in imaging and prostate cancer diagnoses between patients receiving and not receiving 5-ARI therapy.  \nMethods From 2015 to 2020, we collected retrospective data of consecutive patients undergoing prostate biopsy at one centre. We included patients who were biopsy-naïve, had prior negative biopsies, or on active surveillance for low-grade prostate cancer. Clinical and pathological data was collected, including 5-ARI use, Prostate Imaging Reporting and Data System (PIRADS) classification and biopsy results.  \nResults 351 men underwent saturation biopsy with or without targeted biopsies. 54 (15 . 3%) had a history of 5-ARI use. On mpMRI, there was no significant difference between the 5ARI and non-5-ARI groups in PIRADS distribution, number of lesions, and lesion location. Significantly fewer cancers were detected in the 5-ARI group (46 . 3% vs. 68. 0%; p \u003C 0. 01) . There were no significant differences in PIRADS distribution in 5-ARI patients with positive and negative biopsy.  \nConclusion Our study found significant differences in biochemical, imaging and biopsy characteristics between 5-ARI and non-5-ARI groups. While both groups had similar PIRADS distribution, 5-ARI patients had a lower rate of positive biopsies across all PIRADS categories, which may suggest that the use of 5ARI may confound MRI findings. Further studies on how 5-ARI therapy affects the imaging characteristics of prostate cancer should be performed. Keywords 5-alpha reductase inhibitor, Prostate cancer, MRI, Biopsy  \n*Correspondence:  \nKaiying Wang [kaiying.wang@mohh.com.sg](kaiying.wang@mohh.com.sg)  \n1 Department of Urology, National University Hospital, Singapore, Singapore  \n2 Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore  \n3 Department of Surgery, National University Singapore, Singapore, Singapore  \nBackground  \nThere has been increasing recognition of the utility of multiparametric magnetic resonance imaging (mpMRI) in the diagnosis of prostate cancer. With the emergence of several large studies showing MRI before biopsy was superior to biopsy alone [1, 2], both the European Association of Urology (EAU) and American Urological Association (AUA) guidelines were updated to recommend mpMRI prior to biopsy, both for men without previous  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creat","cbCaigk0LPA28c0q","https://ap.wps.com/l/cbCaigk0LPA28c0q","pdf",867663,"English","# Abstract\n# Methods\n# Results\n# Conclusion\n# Background\n# Methods","[{\"question\":\"What question does the study investigate about 5-ARIs and MRI?\",\"answer\":\"It examines how 5-ARI therapy affects mpMRI findings and the diagnostic yield of prostate biopsy compared with patients not receiving 5-ARIs.\"},{\"question\":\"How were participants selected for the comparison?\",\"answer\":\"Retrospective consecutive patients undergoing prostate biopsy from 2015 to 2020 were included, including biopsy-naïve men, men with prior negative biopsies, and men on active surveillance for low-grade prostate cancer.\"},{\"question\":\"What were the main imaging and biopsy findings?\",\"answer\":\"On mpMRI, PIRADS distribution, lesion number, and lesion location were not significantly different between groups, while significantly fewer cancers were detected in the 5-ARI group; the lower positive biopsy rate persisted across PIRADS categories.\"}]","5-alpha reductase inhibitors and MRI prostates: actively reducing prostate sizes and ambiguity | PDF",1790249853,18]