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Rule 1 emphasizes the increased risk of suicidal thoughts in the initial weeks of treatment, mandating prompt notification of a provider for any such thoughts and close monitoring for unusual behavior or worsening depression. Rule 2 highlights the slow onset of action and the necessity of a gradual tapering off period, strictly prohibiting abrupt discontinuation. Rule 3 warns against mixing certain medications, specifically SSRIs with St. John's Wort or MAOIs with other antidepressants like TCAs, SSRIs, or SNRIs, due to potentially dangerous interactions. Rule 4 notes that all psychiatric drugs can decrease blood pressure, advising slow position changes, and can cause weight fluctuations. The document also includes practice questions for assessing comprehension of these rules, focusing on identifying medications with high injury potential, sedating drugs, dangerous drug combinations, and adverse reactions. The practice questions cover scenarios involving Amitriptyline, Diphenhydramine, Colace, Alprazolam, Buspirone, Sertraline, Escitalopram, Citalopram, MAOIs (Phenelzine, Selegiline), Lithium, Ketorolac, St. John's Wort, and Clozapine, reinforcing key teaching points about drug interactions, side effects, and safe administration practices in psychiatric care.",{"@graph":69,"@context":99},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/4-rules-for-antidepressants/27277",{"url":83,"name":65,"@type":85,"author":86,"headline":65,"publisher":89,"fileFormat":92,"description":67,"dateModified":93,"datePublished":93,"encodingFormat":92,"isAccessibleForFree":94,"interactionStatistic":95},"DigitalDocument",{"name":87,"@type":88},"Jiven","Person",{"url":74,"name":90,"@type":91},"DocShare","Organization","application/pdf","2026-05-08",true,{"@type":96,"interactionType":97,"userInteractionCount":4},"InteractionCounter",{"@type":98},"ViewAction","https://schema.org",{"og:url":83,"og:type":101,"og:title":65,"og:site_name":90,"og:description":67},"article",{"robots":103,"canonical":83},"index,follow",{"doc_id":105,"site_id":62},27277,1778274617,{"code":4,"msg":5,"data":108},{"doc_id":105,"user_id":109,"nickname":87,"user_avatar":110,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":111,"file_url":112,"file_type":113,"file_size":114,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":115,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":116,"seo_description":67,"update_tm":106,"read_time":81},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","cbCaimVAeVkX01HE","https://ap.wps.com/l/cbCaimVAeVkX01HE","pdf",885485,"English","4 Rules for Antidepressants | PDF"]