[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-27574-en":3,"doc-seo-27574-105":27,"detail-sidebar-cat-0-en-105":69},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":20,"language":21,"language_code":22,"site_id":23,"html_lang":22,"table_of_contents":15,"faqs":15,"seo_title":24,"seo_description":14,"update_tm":25,"read_time":26},27574,549758146520,"Patrick","https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470",7,"Healthcare","3 Sulfonylureas","This document, titled \"3. Sulfonylureas,\" delves into the mechanism of action, indications, and contraindications of sulfonylurea drugs used in the treatment of type 2 diabetes mellitus. It elaborates on how these oral antidiabetic agents function by stimulating the pancreas's beta cells to release insulin, emphasizing their ineffectiveness when beta cells are compromised. The document outlines the conditions for which sulfonylureas are prescribed, primarily when diet alone is insufficient to control blood glucose levels in type 2 diabetes patients. It also lists potential side effects such as hypoglycemia, anorexia, nausea, vomiting, epigastric discomfort, weight gain, heartburn, and neurological symptoms like weakness and numbness. Contraindications are clearly stated, including diabetic ketoacidosis (DKA), severe infections, and known hypersensitivity. Specific warnings are issued for first-generation sulfonylureas, prohibiting their use in patients with coronary artery disease or liver or renal dysfunction. 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