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The report includes a Quality Assurance statement, study identification, and key personnel, and documents inspection timelines reported to the study director and management. Study procedures cover test material handling, dosing, animal maintenance, antemortem observations, body weight and food consumption measurements, ophthalmology, clinical pathology, anatomical pathology, and data review, review, and re-review steps, culminating in final report review.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/13-week-dietary-toxicity-study-with-red-star-phaffia-yeast-in-rats/269275/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/13-week-dietary-toxicity-study-with-red-star-phaffia-yeast-in-rats/269275.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-15",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What study was conducted and what test material was evaluated?","Question",{"text":112,"@type":113},"The study conducted was a 13-week dietary toxicity study in rats evaluating Red Star⑧ Phaffia Yeast. The report identifies the test material and sponsor-linked product information in the study identification section.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which standards and oversight were referenced for quality assurance?",{"text":117,"@type":113},"Quality assurance was conducted in accordance with FDA Good Laboratory Practice regulations (21 CFR 58.35(b)(6)(7)) and OECD Principles of Good Laboratory Practice. Inspections and findings were reported to the study director and management.",{"name":119,"@type":110,"acceptedAnswer":120},"What types of assessments and measurements were included in the procedures and results?",{"text":121,"@type":113},"Procedures included acclimation, housing and group placement, dose preparation and administration, retention samples, and antemortem observations. Assessments covered body weights, food consumption, ophthalmology, clinical pathology, anatomical pathology, and statistical analyses, followed by summarized results and conclusions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},269275,1789449934,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":129,"read_time":144,"preview_page_count":4},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","APPENDIX12  \nSponsor:  \nUniversal Foods CorporationMilwaukee,Wisconsin  \nFINAL REPORT  \nStudy Title:  \n13-Week Dietary Toxicity Study withRed Star①Phaffia Yeast in Rats  \nAuthor:  \nAnthony L.Kiorpes,DVM,PhD,DABT  \nStudy Completion Date:February 28,1995  \nPerforming Laboratory:  \nHazleton Wisconsin,Inc3301 Kinsman BoulevardMadison,Wisconsin 53704  \nLaboratory Proiect Identification:  \nHWI 6575-100  \nVolume I of II  \nPage 1 of 566  \n# QUALITY ASSURANCE STATEMENT\n\nThis report has been revfewed by the Quality Assurance Unit of HazletonWisconsin,Inc.,In accordance with the Food and Drug Administration(FDA)Good Laboratory Practice Regulations,21 CFR 58.35(b)(6)(7)and theOrganisation for Economic Cooperation and Development(OECD)Principles ofGood Laboratory Practice,C(81)30(Final):The following inspecttons wereconducted and findings reported to the Study Director and management.Written status reports of inspections and findings are issued to Hazletonmanagement monthly according to standard operating procedures.  \nDateInspection DatesReported toDate From To    Phase   Study Directorto Manaqement05/18/9405/19/94Protocol Review05/19/9406/10/9407/11/9407/11/94Dose Preparation07/18/9408/10/9409/14/9409/14/94Sample Collection09/14/9410/10/9409/14/9409/14/94 Clinical Pathology09/14/9410/10/9412/01/9412/08/94 Data Review12/08/9401/10/9512/01/9412/08/94 Data Review12/08/9401/10/9512/01/94  12/08/94 Data Review12/08/9401/10/9512/01/9412/08/94 Data Review12/08/9401/10/9512/01/9412/08/94 Data Review12/08/9401/10/9501/16/9501/23/95 Report Review01/23/9502/10/9502/23/9502/23/95 Report Rereview02/23/9503/10/95  \nt8·95  \nTest Material  \nSponsor  \nStudy Monitor  \nAlternate Study Monitor  \nStudy Director  \nStudy Location  \nStudy TimetableStudy Initiation DateIn-Life Start DateIn-Life End DateStudy Completion Date  \n# STUDY IDENTIFICATION\n\n13-Week Dietary Toxicity Study withRed Star⑧Phaffia Yeast in Rats  \nRed Star①Phaffia Yeast  \nRed Star BioProducts,  \na Division of Universal FoodsCorporation  \n433 East Michigan StreetMilwaukee,Wisconsin 53202  \nGary W.Sanderson,PhDUniversal Foods Corporation433 East Michigan StreetMilwaukee,Wisconsin 53202(414)347-3964  \nSetsuko 0.Jolly,PhDRed Star BioProducts,  \na Division of Universal FoodsCorDoration  \n6143 North 60th StreetMilwaukee,Wisconsin 53218(414)535-4350  \nAnthony L.Kiorpes,DVM,PhD,DABTHazleton Wisconsin,Inc.P.0.Box 7545  \nMadison,Wisconsin 53707(608)241-7226  \nHazleton Wisconsin,Inc.3301 Kinsman BoulevardMadison,Wisconsin 53704  \nJune 2,1994June 14,1994September 16,1994February 28,1995  \n00562  \nToxicology  \nAnthony L.Kiorpes,DVM,PhDDiplomate,ABTStudy Director  \nJames R.BeduhnStudy Coordinator  \nToxicology OperationsRobert YoungSupervisorRodent Toxicology  \nDose PreparationDixie BusheeSupervisor  \nLaboratory Animal MedicineCindy J.Cary,DVMDiplomate,ACLAMSupervisor  \nClinical PathologyRobert L.Ha11,DVM,PhDDiplomate,ACVPClinical Pathologist  \nRonald MarkevitchSupervisor  \n# KEY PERSONNEL\n\nAnatomical PatholoqyThomas E.Palmer,PhDAnatomical Pathologist  \nDeborah Pirkel  \nSuperyisor  \nNecropsy  \nJack Serfort  \nSupervisor  \nNecropsy  \nRichard Becker  \nSupervisor  \nHistology  \nVitamin ChemistrySharon PochronSupervisor  \nQuality AssuranceSherry R.W.PetselManager  \nOphthalmology ConsultantFrederick A.Nothnagel,DVMVeterinary Examiner  \nCONTENTS  \nVOLUME I OF II  \nQUALITY ASSURANCE STATEMENTSTUDY IDENTIFICATIONKEY PERSONNELABSTRACTOBJECTIVE  \nREGULATORY COMPLIANCEMAINTENANCE OF RAW DATA,RECORDS,AND SPECIMENS  \nTEST MATERIAL AND CARRIER  \nIdentification and CharacterizationStorage ConditionsReserve SamplesDispositionSafety Precautions  \nTEST SYSTEM  \nTest Animal  \nJustification  \nIdentification  \nSTUDY DESIGN  \nPROCEDURES  \nAcclimation  \nHousing and Maintenance  \nPlacement of Animals into GroupsDose PreparationRetention SamplesDose AnalysesDose AdministrationAntemortem ObservationsBody WeightsFood Consumption0nhthalmologyClinical PathologyAnatomical PathologyStatistical Analyses  \nPage  \n2  \n3  \n4  \n8  \n10  \n10  \n10 ","cbCailUvh4gG6GyD","https://ap.wps.com/l/cbCailUvh4gG6GyD","pdf",1741480,26,"English","# Quality Assurance Statement\n## Study Identification\n## Key Personnel\n# Contents (Volume I of II)\n## Quality Assurance Statements\n## Study Identification\n## Key Personnel\n## Abstract and Objective\n## Regulatory Compliance\n## Maintenance of Raw Data, Records, and Specimens\n## Test Material and Carrier\n## Test System\n## Study Design\n## Procedures\n## Results\n## Conclusion\n## Signatures\n## References\n# Ophthalmology and Pathology Reports\n# Codes, Abbreviations, and Units\n## General Codes and Abbreviations\n## Codes for Clinical Pathology\n## Codes for Anatomical Pathology\n# Tables and Appendices\n## Protocol Deviations\n## Material Safety Data Sheet and Certificate of Analysis\n## Individual Animal Fate and Antemortem Observations","[{\"question\":\"What study was conducted and what test material was evaluated?\",\"answer\":\"The study conducted was a 13-week dietary toxicity study in rats evaluating Red Star⑧ Phaffia Yeast. The report identifies the test material and sponsor-linked product information in the study identification section.\"},{\"question\":\"Which standards and oversight were referenced for quality assurance?\",\"answer\":\"Quality assurance was conducted in accordance with FDA Good Laboratory Practice regulations (21 CFR 58.35(b)(6)(7)) and OECD Principles of Good Laboratory Practice. Inspections and findings were reported to the study director and management.\"},{\"question\":\"What types of assessments and measurements were included in the procedures and results?\",\"answer\":\"Procedures included acclimation, housing and group placement, dose preparation and administration, retention samples, and antemortem observations. Assessments covered body weights, food consumption, ophthalmology, clinical pathology, anatomical pathology, and statistical analyses, followed by summarized results and conclusions.\"}]","13-Week Dietary Toxicity Study with Red Star⑧ Phaffia Yeast in Rats | PDF",66]